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Cryo-EM structure of hZnT7-Fab complex in zinc state 1, determined in heterogeneous conformations- one subunit in an inward-facing zinc-bound and the other in an outward-facing zinc-unbound conformation

Electron Microscopy
2.68Å resolution
PDB entry 8j80 coloured by chain, front view.
PDB entry 8j80 coloured by chain, side view.
PDB entry 8j80 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero hexamer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: ZNT7 proton-coupled zinc antiporter complex and antibody
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Multimeric state: hetero hexamer
Accessible surface area: 61358.41 Å2
Buried surface area: 16614.24 Å2
Dissociation area: 2,660.76 Å2
Dissociation energy (ΔGdiss): -5.33 kcal/mol
Dissociation entropy (TΔSdiss): 29.15 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-229583

Macromolecules

Zinc transporter 7
Chains: A, B
Length: 390 amino acids
Theoretical weight: 43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8NEW0 (Residues: 1-376; Coverage: 100%)
Gene names: SLC30A7, ZNT7, ZNTL2
Pfam: Cation efflux family
Zinc transporter 7 in PDB entry 8j80, assembly 1, front view.
Zinc transporter 7 in PDB entry 8j80, assembly 1, side view.
Zinc transporter 7 in PDB entry 8j80, assembly 1, top view.
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Light chain of YN7114-08 Fab
Chains: C, D
Length: 218 amino acids
Theoretical weight: 24.14 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Light chain of YN7114-08 Fab in PDB entry 8j80, assembly 1, front view.
Light chain of YN7114-08 Fab in PDB entry 8j80, assembly 1, side view.
Light chain of YN7114-08 Fab in PDB entry 8j80, assembly 1, top view.
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Heavy chain of YN7114-08 Fab
Chains: E, F
Length: 234 amino acids
Theoretical weight: 24.97 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Heavy chain of YN7114-08 Fab in PDB entry 8j80, assembly 1, front view.
Heavy chain of YN7114-08 Fab in PDB entry 8j80, assembly 1, side view.
Heavy chain of YN7114-08 Fab in PDB entry 8j80, assembly 1, top view.
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