› 8jhq

Electron Microscopy
3.6Å resolution

Cryo-EM structure of human S1P transporter SPNS2 bound with S1P

Released:
DOI: 10.2210/pdb8jhq/pdb
PDB entry 8jhq coloured by chain, front view.
PDB entry 8jhq coloured by chain, side view.
PDB entry 8jhq coloured by chain, top view.
Source organisms:
Primary publication:
Molecular basis of Spns2-facilitated sphingosine-1-phosphate transport.
Pang B, Yu L, Li T, Jiao H, Wu X, Wang J, He R, Zhang Y, Wang J, Hu H, Dai W, Chen L, Ren R
Cell Res (2023)
PMID: 38123824
Related structures: EMD-36284

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-238792 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sphingosine-1-phosphate transporter SPNS2; Starch synthase catalytic domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 764 amino acids
Theoretical weight: 82.09 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: Q8IVW8 (Residues: 1-222, 223-549; Coverage: 100%)
  • Canonical: Q9V2J8 (Residues: 218-413; Coverage: 45%)
Gene names: PAB2292, SPNS2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand S1P 1 x S1P
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-36284
Expression system: Homo sapiens

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