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Cryo-EM structure of human S1P transporter SPNS2 bound with S1P

Electron Microscopy
3.6Å resolution
PDB entry 8jhq coloured by chain, front view.
PDB entry 8jhq coloured by chain, side view.
PDB entry 8jhq coloured by chain, top view.
Source organisms:
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Sphingosine-1-phosphate transporter SPNS2, Starch synthase catalytic domain-containing protein
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Multimeric state: monomeric
Accessible surface area: 21388.19 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-238792

Macromolecules

Sphingosine-1-phosphate transporter SPNS2; Starch synthase catalytic domain-containing protein
Chain: A
Length: 764 amino acids
Theoretical weight: 82.09 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: Q8IVW8 (Residues: 1-222, 223-549; Coverage: 100%)
  • Canonical: Q9V2J8 (Residues: 218-413; Coverage: 45%)
    • nullnull
Gene names: PAB2292, SPNS2
Pfam:
Sphingosine-1-phosphate transporter SPNS2 in PDB entry 8jhq, assembly 1, front view.
Sphingosine-1-phosphate transporter SPNS2 in PDB entry 8jhq, assembly 1, side view.
Sphingosine-1-phosphate transporter SPNS2 in PDB entry 8jhq, assembly 1, top view.
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