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Cryo-EM structure of the gastric proton pump with bound DQ-21

Electron Microscopy
2.26Å resolution
PDB entry 8jmn coloured by chain, front view.
PDB entry 8jmn coloured by chain, side view.
PDB entry 8jmn coloured by chain, top view.
Source organism: Sus scrofa
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Hydrogen:potassium-exchanging ATPase complex
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Multimeric state: hetero dimer
Accessible surface area: 52793.63 Å2
Buried surface area: 11068.88 Å2
Dissociation area: 2,836.69 Å2
Dissociation energy (ΔGdiss): 20.57 kcal/mol
Dissociation entropy (TΔSdiss): 14.86 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148371
Complex Portal ID: CPX-2195

Macromolecules

Potassium-transporting ATPase alpha chain 1
Chain: A
Length: 1033 amino acids
Theoretical weight: 114.33 KDa
Source organism: Sus scrofa
Expression system: Homo sapiens
UniProt:
  • Canonical: P19156 (Residues: 2-1034; Coverage: 100%)
Gene name: ATP4A
Pfam:
Sodium/potassium-transporting ATPase subunit alpha in PDB entry 8jmn, assembly 1, front view.
Sodium/potassium-transporting ATPase subunit alpha in PDB entry 8jmn, assembly 1, side view.
Sodium/potassium-transporting ATPase subunit alpha in PDB entry 8jmn, assembly 1, top view.
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Potassium-transporting ATPase subunit beta
Chain: B
Length: 290 amino acids
Theoretical weight: 33.11 KDa
Source organism: Sus scrofa
Expression system: Homo sapiens
UniProt:
  • Canonical: P18434 (Residues: 1-290; Coverage: 100%)
Gene name: ATP4B
Pfam: Sodium / potassium ATPase beta chain
Potassium-transporting ATPase subunit beta in PDB entry 8jmn, assembly 1, front view.
Potassium-transporting ATPase subunit beta in PDB entry 8jmn, assembly 1, side view.
Potassium-transporting ATPase subunit beta in PDB entry 8jmn, assembly 1, top view.
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