PMID: 
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Structure-Based Optimization and Biological Evaluation of Potent and Selective MMP-7 Inhibitors for Kidney Fibrosis.
Abe-Sato K,
Tabuse H,
Kanazawa H,
Kamitani M,
Endo M,
Tokura S,
Wakabayashi S,
Yahara T,
Takeda T,
Hitaka K,
Gunji E,
Kojima N,
Oka Y
J Med Chem (2023)
Abstract
Matrix metalloproteinase-7 (MMP-7) has been shown to play important roles in pathophysiological processes involved in the development/progression of diseases such as cancer and fibrosis. We discovered selective MMP-7 inhibitors composed of arylsulfonamide, carboxylate, and short peptides by a molecular hybridization approach. These compounds interacted with MMP-7 via multiple hydrogen bonds in the cocrystal structures. To obtain compounds for in vivo evaluation, we attempted structural optimization, particularly targeting Tyr167 at the S3 subsite through structure-based drug design, and identified compound
We are not aware of any publication which cites or mentions this structure.