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CryoEM structure of 3-phenylpropionate/cinnamic acid dioxygenase HcaE-HcaF complex

Source organism: Escherichia coli K-12
Biochemical function: dioxygenase activity
Biological process: 3-phenylpropionate catabolic process
Cellular component: 3-phenylpropionate dioxygenase complex

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EC 1.14.12.19: 3-phenylpropanoate dioxygenase

Reaction catalysed:
(2E)-3-phenylprop-2-enoate + NADH + O(2) = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + NAD(+)
Systematic name:
3-phenylpropanoate,NADH:oxygen oxidoreductase (2,3-hydroxylating)
Alternative Name(s):
  • 3-phenylpropionate dioxygenase
  • Hca dioxygenase
  • HcaA1A2CD

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00866
Domain description: Ring hydroxylating beta subunit
Occurring in:
  1. 3-phenylpropionate/cinnamic acid dioxygenase subunit beta
The deposited structure of PDB entry 8k0a contains 3 copies of Pfam domain PF00866 (Ring hydroxylating beta subunit) in 3-phenylpropionate/cinnamic acid dioxygenase subunit beta. Showing 1 copy in chain B.

PF00848
Domain description: Ring hydroxylating alpha subunit (catalytic domain)
Occurring in:
  1. 3-phenylpropionate/cinnamic acid dioxygenase subunit alpha
The deposited structure of PDB entry 8k0a contains 3 copies of Pfam domain PF00848 (Ring hydroxylating alpha subunit (catalytic domain)) in 3-phenylpropionate/cinnamic acid dioxygenase subunit alpha. Showing 1 copy in chain A.

PF00355
Domain description: Rieske [2Fe-2S] domain
Occurring in:
  1. 3-phenylpropionate/cinnamic acid dioxygenase subunit alpha
The deposited structure of PDB entry 8k0a contains 3 copies of Pfam domain PF00355 (Rieske [2Fe-2S] domain) in 3-phenylpropionate/cinnamic acid dioxygenase subunit alpha. Showing 1 copy in chain A.

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