› 8kci

Electron Microscopy
3.94Å resolution

ATP-bound hMRP5 outward-open

Released:
DOI: 10.2210/pdb8kci/pdb
PDB entry 8kci coloured by chain, front view.
PDB entry 8kci coloured by chain, side view.
PDB entry 8kci coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Inhibition and transport mechanisms of the ABC transporter hMRP5.
Huang Y, Xue C, Bu R, Wu C, Li J, Zhang J, Chen J, Shi Z, Chen Y, Wang Y, Liu Z
Nat Commun 15 4811 (2024)
PMID: 38844452
Related structures: EMD-37105

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-246575 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATP-binding cassette sub-family C member 5 Chain: A
Molecule details ›
Chain: A
Length: 1437 amino acids
Theoretical weight: 160.82 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O15440 (Residues: 1-1437; Coverage: 100%)
Gene names: ABCC5, MRP5
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand ATP 2 x ATP
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.94Å
Relevant EMDB volumes: EMD-37105
Expression system: Homo sapiens

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