› 8khf

Electron Microscopy
3.13Å resolution

Structure of the human ATP synthase bound to bedaquiline (membrane domain)

Released:
DOI: 10.2210/pdb8khf/pdb
PDB entry 8khf coloured by chain, front view.
PDB entry 8khf coloured by chain, side view.
PDB entry 8khf coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Lai Y, Zhang Y
Related structures: EMD-37243

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero nonadecamer (preferred)
PDBe Complex ID:
PDB-CPX-216671 (preferred)
Entry contents:
12 distinct polypeptide molecules
Macromolecules (12 distinct):
ATP synthase F(0) complex subunit C1, mitochondrial Chains: 1, 2, 3, 4, 5, 6, 7, 8
Molecule details ›
Chains: 1, 2, 3, 4, 5, 6, 7, 8
Length: 75 amino acids
Theoretical weight: 7.61 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P05496 (Residues: 62-136; Coverage: 55%)
Gene names: ATP5G1, ATP5MC1
Sequence domains: ATP synthase subunit C
ATP synthase subunit gamma, mitochondrial Chain: G
Molecule details ›
Chain: G
Length: 273 amino acids
Theoretical weight: 30.21 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P36542 (Residues: 26-298; Coverage: 92%)
Gene names: ATP5C, ATP5C1, ATP5CL1, ATP5F1C
Sequence domains: ATP synthase
ATP synthase subunit delta, mitochondrial Chain: H
Molecule details ›
Chain: H
Length: 146 amino acids
Theoretical weight: 15.03 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P30049 (Residues: 23-168; Coverage: 87%)
Gene names: ATP5D, ATP5F1D
Sequence domains:
ATP synthase subunit epsilon, mitochondrial Chain: I
Molecule details ›
Chain: I
Length: 51 amino acids
Theoretical weight: 5.79 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P56381 (Residues: 1-51; Coverage: 100%)
Gene names: ATP5E, ATP5F1E
Sequence domains: Mitochondrial ATP synthase epsilon chain
ATP synthase F(0) complex subunit B1, mitochondrial Chain: K
Molecule details ›
Chain: K
Length: 214 amino acids
Theoretical weight: 24.66 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P24539 (Residues: 43-256; Coverage: 84%)
Gene names: ATP5F1, ATP5PB
Sequence domains: Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
ATP synthase subunit d, mitochondrial Chain: M
Molecule details ›
Chain: M
Length: 160 amino acids
Theoretical weight: 18.38 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O75947 (Residues: 2-161; Coverage: 99%)
Gene names: ATP5H, ATP5PD, My032
Sequence domains: ATP synthase D chain, mitochondrial (ATP5H)
ATP synthase subunit a Chain: N
Molecule details ›
Chain: N
Length: 226 amino acids
Theoretical weight: 24.83 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00846 (Residues: 1-226; Coverage: 100%)
Gene names: ATP6, ATPASE6, MT-ATP6, MTATP6
Sequence domains: ATP synthase A chain
ATP synthase subunit ATP5MJ, mitochondrial Chain: P
Molecule details ›
Chain: P
Length: 58 amino acids
Theoretical weight: 6.67 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P56378 (Residues: 1-58; Coverage: 100%)
Gene names: ATP5MJ, ATP5MPL, C14orf2, MP68, PRO1574
Sequence domains: Mitochondrial proteolipid
ATP synthase protein 8 Chain: Q
Molecule details ›
Chain: Q
Length: 68 amino acids
Theoretical weight: 8 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P03928 (Residues: 1-68; Coverage: 100%)
Gene names: ATP8, ATPASE8, MT-ATP8, MTATP8
Sequence domains: ATP synthase protein 8
ATP synthase subunit f, mitochondrial Chain: R
Molecule details ›
Chain: R
Length: 93 amino acids
Theoretical weight: 10.8 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P56134 (Residues: 2-94; Coverage: 99%)
Gene names: ATP5J2, ATP5JL, ATP5MF
Sequence domains: Mitochondrial F1F0-ATP synthase, subunit f
ATP synthase subunit g, mitochondrial Chain: S
Molecule details ›
Chain: S
Length: 102 amino acids
Theoretical weight: 11.31 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O75964 (Residues: 2-103; Coverage: 99%)
Gene names: ATP5L, ATP5MG
Sequence domains: Mitochondrial ATP synthase g subunit
ATP synthase subunit e, mitochondrial Chain: T
Molecule details ›
Chain: T
Length: 69 amino acids
Theoretical weight: 7.95 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P56385 (Residues: 1-69; Coverage: 100%)
Gene names: ATP5I, ATP5K, ATP5ME
Sequence domains: ATP synthase E chain

Ligands and Environments

1 bound ligand:
Ligand BQ1 1 x BQ1
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.13Å
Relevant EMDB volumes: EMD-37243

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