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Monkeypox virus VP39 in complex with SAH and cap0

Source organisms:
Biochemical function: methyltransferase activity
Biological process: methylation
Cellular component: virion component

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EC 2.1.1.57: Methyltransferase cap1

Reaction catalysed:
S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-[mRNA]
Systematic name:
S-adenosyl-L-methionine:5'-(N(7)-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] 2-O-methyltransferase
Alternative Name(s):
  • Cap1-MTase
  • MTR1
  • Messenger RNA (nucleoside-2'-)-methyltransferase
  • Messenger ribonucleate nucleoside 2'-methyltransferase
  • S-adenosyl-L-methionine:mRNA (nucleoside-2'-O)-methyltransferase
  • mRNA (nucleoside-2'-O)-methyltransferase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01358
Domain description: Poly A polymerase regulatory subunit
Occurring in:
  1. Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase
The deposited structure of PDB entry 8oiv contains 2 copies of Pfam domain PF01358 (Poly A polymerase regulatory subunit) in Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase. Showing 1 copy in chain A.

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