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Human tRNA guanine transglycosylase (TGT) bound to tRNAAsp

Electron Microscopy
3.3Å resolution
PDB entry 8omr coloured by chain, front view.
PDB entry 8omr coloured by chain, side view.
PDB entry 8omr coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 2 distinct polypeptide molecules
1 distinct RNA molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: tRNA-guanine transglycosylase complex and RNA
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Multimeric state: hetero trimer
Accessible surface area: 43439.39 Å2
Buried surface area: 7202.03 Å2
Dissociation area: 2,116.32 Å2
Dissociation energy (ΔGdiss): 17.53 kcal/mol
Dissociation entropy (TΔSdiss): 14.69 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-238422

Macromolecules

Queuine tRNA-ribosyltransferase catalytic subunit 1
Chain: A
Length: 405 amino acids
Theoretical weight: 44.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BXR0 (Residues: 1-403; Coverage: 100%)
Gene names: QTRT1, TGT, TGUT
Pfam: Queuine tRNA-ribosyltransferase
Queuine tRNA-ribosyltransferase catalytic subunit 1 in PDB entry 8omr, assembly 1, front view.
Queuine tRNA-ribosyltransferase catalytic subunit 1 in PDB entry 8omr, assembly 1, side view.
Queuine tRNA-ribosyltransferase catalytic subunit 1 in PDB entry 8omr, assembly 1, top view.
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Queuine tRNA-ribosyltransferase accessory subunit 2
Chain: B
Length: 415 amino acids
Theoretical weight: 46.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H974 (Residues: 1-415; Coverage: 100%)
Gene names: QTRT2, QTRTD1
Pfam: Queuine tRNA-ribosyltransferase
Queuine tRNA-ribosyltransferase accessory subunit 2 in PDB entry 8omr, assembly 1, front view.
Queuine tRNA-ribosyltransferase accessory subunit 2 in PDB entry 8omr, assembly 1, side view.
Queuine tRNA-ribosyltransferase accessory subunit 2 in PDB entry 8omr, assembly 1, top view.
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RNA chain C
Name: tRNAAsp
Representative chains: C
Length: 75 nucleotides
Theoretical weight: 24.15 KDa
Rfam: tRNA
tRNAAsp in PDB entry 8omr, assembly 1, front view.
tRNAAsp in PDB entry 8omr, assembly 1, side view.
tRNAAsp in PDB entry 8omr, assembly 1, top view.
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