› 8owx

X-ray diffraction
2.6Å resolution

Crystal Structure of METTL6 bound to SAH

Released:
DOI: 10.2210/pdb8owx/pdb
PDB entry 8owx coloured by chain, front view.
PDB entry 8owx coloured by chain, side view.
PDB entry 8owx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase.
Throll P, G Dolce L, Rico-Lastres P, Arnold K, Tengo L, Basu S, Kaiser S, Schneider R, Kowalinski E
Nat Struct Mol Biol (2024)
PMID: 38918637

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186185 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
tRNA N(3)-methylcytidine methyltransferase METTL6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 275 amino acids
Theoretical weight: 32.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8TCB7 (Residues: 1-271; Coverage: 95%)
Gene name: METTL6
Sequence domains: Methyltransferase domain

Ligands and Environments

2 bound ligands:
Ligand SAH 2 x SAH
Ligand B3P 1 x B3P
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-1
Spacegroup: P43
Unit cell:
a: 82.856Å b: 82.856Å c: 130.39Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.217 0.25
Expression system: Escherichia coli

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