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Crystal Structure of METTL6 bound to SAH

X-ray diffraction
2.601Å resolution
PDB entry 8owx coloured by chain, front view.
PDB entry 8owx coloured by chain, side view.
PDB entry 8owx coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: tRNA N(3)-methylcytidine methyltransferase METTL6
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Multimeric state: monomeric
Accessible surface area: 11258.09 Å2
Buried surface area: 365.37 Å2
Dissociation area: 182.68 Å2
Dissociation energy (ΔGdiss): -6.87 kcal/mol
Dissociation entropy (TΔSdiss): 3.94 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-186185
Assembly 2
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Assembly Name: tRNA N(3)-methylcytidine methyltransferase METTL6
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Multimeric state: monomeric
Accessible surface area: 12165.9 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-186185

Macromolecules

tRNA N(3)-methylcytidine methyltransferase METTL6
Chains: A, B
Length: 275 amino acids
Theoretical weight: 32.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8TCB7 (Residues: 1-271; Coverage: 95%)
Gene name: METTL6
Pfam: Methyltransferase domain
tRNA N(3)-methylcytidine methyltransferase METTL6 in PDB entry 8owx, assembly 1, front view.
tRNA N(3)-methylcytidine methyltransferase METTL6 in PDB entry 8owx, assembly 1, side view.
tRNA N(3)-methylcytidine methyltransferase METTL6 in PDB entry 8owx, assembly 1, top view.
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