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Cryo-EM structure of ATP8B1-CDC50A in E1P conformation

Source organism: Homo sapiens
Biochemical function: aminophospholipid flippase activity
Biological process: aminophospholipid translocation
Cellular component: phospholipid-translocating ATPase complex

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EC 7.6.2.1: P-type phospholipid transporter

Reaction catalysed:
ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)
Systematic name:
ATP phosphohydrolase (P-type, phospholipid-flipping)
Alternative Name(s):
  • Aminophospholipid-transporting ATPase
  • Flippase
  • Phospholipid-transporting ATPase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF03381
Domain description: LEM3 (ligand-effect modulator 3) family / CDC50 family
Occurring in:
  1. Cell cycle control protein 50A
The deposited structure of PDB entry 8ox6 contains 1 copy of Pfam domain PF03381 (LEM3 (ligand-effect modulator 3) family / CDC50 family) in Cell cycle control protein 50A. Showing 1 copy in chain B.

PF16212
Domain description: Phospholipid-translocating P-type ATPase C-terminal
Occurring in:
  1. Phospholipid-transporting ATPase IC
The deposited structure of PDB entry 8ox6 contains 1 copy of Pfam domain PF16212 (Phospholipid-translocating P-type ATPase C-terminal) in Phospholipid-transporting ATPase IC. Showing 1 copy in chain A.

PF13246
Domain description: Cation transport ATPase (P-type)
Occurring in:
  1. Phospholipid-transporting ATPase IC
The deposited structure of PDB entry 8ox6 contains 1 copy of Pfam domain PF13246 (Cation transport ATPase (P-type)) in Phospholipid-transporting ATPase IC. Showing 1 copy in chain A (this domain is out of the observed residue ranges!).

PF00122
Domain description: E1-E2 ATPase
Occurring in:
  1. Phospholipid-transporting ATPase IC
The deposited structure of PDB entry 8ox6 contains 1 copy of Pfam domain PF00122 (E1-E2 ATPase) in Phospholipid-transporting ATPase IC. Showing 1 copy in chain A.

PF16209
Domain description: Phospholipid-translocating ATPase N-terminal
Occurring in:
  1. Phospholipid-transporting ATPase IC
The deposited structure of PDB entry 8ox6 contains 1 copy of Pfam domain PF16209 (Phospholipid-translocating ATPase N-terminal) in Phospholipid-transporting ATPase IC. Showing 1 copy in chain A.

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