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Cryo-EM structure of ATP8B1-CDC50A in E1P conformation

Electron Microscopy
2.39Å resolution
PDB entry 8ox6 coloured by chain, front view.
PDB entry 8ox6 coloured by chain, side view.
PDB entry 8ox6 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: ATP8B1-CDC50A P4-ATPase complex
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Multimeric state: hetero dimer
Accessible surface area: 37725.18 Å2
Buried surface area: 9988.0 Å2
Dissociation area: 4,106.48 Å2
Dissociation energy (ΔGdiss): 50.27 kcal/mol
Dissociation entropy (TΔSdiss): 15.14 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-128957
Complex Portal ID: CPX-6282

Macromolecules

Phospholipid-transporting ATPase IC
Chain: A
Length: 1185 amino acids
Theoretical weight: 136.28 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: O43520 (Residues: 1-1185; Coverage: 95%)
Gene names: ATP8B1, ATPIC, FIC1, PFIC
Pfam:
Phospholipid-transporting ATPase IC in PDB entry 8ox6, assembly 1, front view.
Phospholipid-transporting ATPase IC in PDB entry 8ox6, assembly 1, side view.
Phospholipid-transporting ATPase IC in PDB entry 8ox6, assembly 1, top view.
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Cell cycle control protein 50A
Chain: B
Length: 365 amino acids
Theoretical weight: 41.09 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q9NV96 (Residues: 1-361; Coverage: 100%)
Gene names: C6orf67, CDC50A, TMEM30A
Pfam: LEM3 (ligand-effect modulator 3) family / CDC50 family
Cell cycle control protein 50A in PDB entry 8ox6, assembly 1, front view.
Cell cycle control protein 50A in PDB entry 8ox6, assembly 1, side view.
Cell cycle control protein 50A in PDB entry 8ox6, assembly 1, top view.
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