› 8p3q

Electron Microscopy
2.95Å resolution

Homomeric GluA2 flip R/G-unedited Q/R-edited F231A mutant in tandem with TARP gamma-2, desensitized conformation 3

Released:
DOI: 10.2210/pdb8p3q/pdb
PDB entry 8p3q coloured by chain, front view.
PDB entry 8p3q coloured by chain, side view.
PDB entry 8p3q coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor.
Zhang D, Ivica J, Krieger JM, Ho H, Yamashita K, Stockwell I, Baradaran R, Cais O, Greger IH
OpenAccess logo Nature (2023)
PMID: 37704721
Related structures: EMD-17392

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148613 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Glutamate receptor 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 883 amino acids
Theoretical weight: 98.91 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P19491 (Residues: 1-883; Coverage: 100%)
  • Best match: P19491-2 (Residues: 1-883)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Voltage-dependent calcium channel gamma-2 subunit Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 323 amino acids
Theoretical weight: 35.94 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q71RJ2 (Residues: 1-323; Coverage: 100%)
Gene names: Cacng2, Stg
Sequence domains: PMP-22/EMP/MP20/Claudin family

Ligands and Environments

3 bound ligands:
Ligand PLM 7 x PLM
Ligand OLC 4 x OLC
Ligand POV 5 x POV
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.95Å
Relevant EMDB volumes: EMD-17392
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Tuning synaptic strength by regulation of AMPA glutamate receptor localization.
Stockwell et al. (2024)
1 more