Function and Biology

CryoEM structure of a GroEL7-GroES7 cage with encapsulated ordered substrate MetK in the presence of ADP-BeFx

Source organism: Escherichia coli
Biochemical function: identical protein binding
Biological process: chaperone cofactor-dependent protein refolding
Cellular component: cytosol

EC 5.6.1.7: Chaperonin ATPase

Reaction catalysed:
ATP + H(2)O + a folded polypeptide = ADP + phosphate + an unfolded polypeptide
Systematic name:
ATP phosphohydrolase (polypeptide-unfolding)
Alternative Name(s):
  • Chaperonin

EC 2.5.1.6: Methionine adenosyltransferase

Reaction catalysed:
ATP + L-methionine + H(2)O = phosphate + diphosphate + S-adenosyl-L-methionine
Systematic name:
ATP:L-methionine S-adenosyltransferase
Alternative Name(s):
  • ATP-methionine adenosyltransferase
  • Adenosylmethionine synthetase
  • AdoMet synthetase
  • Methionine S-adenosyltransferase
  • Methionine-activating enzyme
  • S-adenosyl-L-methionine synthetase
  • S-adenosylmethionine synthase
  • S-adenosylmethionine synthetase

Sequence families

Pfam Protein families (Pfam)
PF00166
Domain description: Chaperonin 10 Kd subunit
Occurring in:
  1. Co-chaperonin GroES
The deposited structure of PDB entry 8p4o contains 7 copies of Pfam domain PF00166 (Chaperonin 10 Kd subunit) in Co-chaperonin GroES. Showing 1 copy in chain H [auth O].

PF00118
Domain description: TCP-1/cpn60 chaperonin family
Occurring in:
  1. Chaperonin GroEL
The deposited structure of PDB entry 8p4o contains 7 copies of Pfam domain PF00118 (TCP-1/cpn60 chaperonin family) in Chaperonin GroEL. Showing 1 copy in chain A.

PF02773
Domain description: S-adenosylmethionine synthetase, C-terminal domain
Occurring in:
  1. S-adenosylmethionine synthase
The deposited structure of PDB entry 8p4o contains 1 copy of Pfam domain PF02773 (S-adenosylmethionine synthetase, C-terminal domain) in S-adenosylmethionine synthase. Showing 1 copy in chain O [auth 1].

PF02772
Domain description: S-adenosylmethionine synthetase, central domain
Occurring in:
  1. S-adenosylmethionine synthase
The deposited structure of PDB entry 8p4o contains 1 copy of Pfam domain PF02772 (S-adenosylmethionine synthetase, central domain) in S-adenosylmethionine synthase. Showing 1 copy in chain O [auth 1].

PF00438
Domain description: S-adenosylmethionine synthetase, N-terminal domain
Occurring in:
  1. S-adenosylmethionine synthase
The deposited structure of PDB entry 8p4o contains 1 copy of Pfam domain PF00438 (S-adenosylmethionine synthetase, N-terminal domain) in S-adenosylmethionine synthase. Showing 1 copy in chain O [auth 1].