8p7l

Electron Microscopy
2.1Å resolution

Cryo-EM structure of CDK7 subunit of CAK in complex with inhibitor LDC4297

Released:

Function and Biology Details

Reactions catalysed:
ATP + a protein = ADP + a phosphoprotein
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-241940 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
CDK-activating kinase assembly factor MAT1 Chain: H
Molecule details ›
Chain: H
Length: 328 amino acids
Theoretical weight: 38.13 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P51948 (Residues: 1-309; Coverage: 100%)
Gene names: CAP35, MAT1, MNAT1, RNF66
Sequence domains:
Cyclin-dependent kinase 7 Chain: J
Molecule details ›
Chain: J
Length: 379 amino acids
Theoretical weight: 42.11 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P50613 (Residues: 1-346; Coverage: 100%)
Gene names: CAK, CAK1, CDK7, CDKN7, MO15, STK1
Sequence domains: Protein kinase domain

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.1Å
Relevant EMDB volumes: EMD-17536
Expression system: Trichoplusia ni