› › Structure analysis

Cryo-EM structure of CDK7 subunit of CAK in complex with inhibitor LDC4297

Electron Microscopy
2.1Å resolution
PDB entry 8p7l coloured by chain, front view.
PDB entry 8p7l coloured by chain, side view.
PDB entry 8p7l coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Cyclin-dependent kinase 7 and CDK-activating kinase assembly factor MAT1
hide full assembly name
Multimeric state: hetero dimer
Accessible surface area: 14819.73 Å2
Buried surface area: 1997.2 Å2
Dissociation area: 998.6 Å2
Dissociation energy (ΔGdiss): 8.12 kcal/mol
Dissociation entropy (TΔSdiss): 9.95 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-241940

Macromolecules

CDK-activating kinase assembly factor MAT1
Chain: H
Length: 328 amino acids
Theoretical weight: 38.13 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P51948 (Residues: 1-309; Coverage: 100%)
Gene names: CAP35, MAT1, MNAT1, RNF66
Pfam:
CDK-activating kinase assembly factor MAT1 in PDB entry 8p7l, assembly 1, front view.
CDK-activating kinase assembly factor MAT1 in PDB entry 8p7l, assembly 1, side view.
CDK-activating kinase assembly factor MAT1 in PDB entry 8p7l, assembly 1, top view.
Molecule details ›

Search similar proteins

Cyclin-dependent kinase 7
Chain: J
Length: 379 amino acids
Theoretical weight: 42.11 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P50613 (Residues: 1-346; Coverage: 100%)
Gene names: CAK, CAK1, CDK7, CDKN7, MO15, STK1
Pfam: Protein kinase domain
Cyclin-dependent kinase 7 in PDB entry 8p7l, assembly 1, front view.
Cyclin-dependent kinase 7 in PDB entry 8p7l, assembly 1, side view.
Cyclin-dependent kinase 7 in PDB entry 8p7l, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links