› 8paf

X-ray diffraction
2.1Å resolution

Crystal structure of human Histidine Triad Nucleotide-Binding Protein 1 in complex with 5'-O-[N-(3-Indolepropionic acid)sulfamoyl] 2-aminoethenoadenosine

Released:
DOI: 10.2210/pdb8paf/pdb
PDB entry 8paf coloured by chain, front view.
PDB entry 8paf coloured by chain, side view.
PDB entry 8paf coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Dolot RM, Dillenburg M, Wagner CR

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156024 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenosine 5'-monophosphoramidase HINT1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 126 amino acids
Theoretical weight: 13.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P49773 (Residues: 1-126; Coverage: 100%)
Gene names: HINT, HINT1, PKCI1, PRKCNH1
Sequence domains: HIT domain

Ligands and Environments

1 bound ligand:
Ligand XKK 1 x XKK
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU PhotonJet-S
Spacegroup: C2
Unit cell:
a: 79.192Å b: 46.55Å c: 64.105Å
α: 90° β: 94.844° γ: 90°
R-values:
R R work R free
0.138 0.136 0.187
Expression system: Escherichia coli BL21(DE3)

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