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Crystal structure of human Histidine Triad Nucleotide-Binding Protein 1 in complex with 5'-O-[N-(3-Indolepropionic acid)sulfamoyl] 2-aminoethenoadenosine

X-ray diffraction
2.1Å resolution
PDB entry 8paf coloured by chain, front view.
PDB entry 8paf coloured by chain, side view.
PDB entry 8paf coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Adenosine 5'-monophosphoramidase HINT1
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Multimeric state: homo dimer
Accessible surface area: 9577.32 Å2
Buried surface area: 3965.53 Å2
Dissociation area: 1,982.77 Å2
Dissociation energy (ΔGdiss): 23.8 kcal/mol
Dissociation entropy (TΔSdiss): 11.79 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-156024

Macromolecules

Adenosine 5'-monophosphoramidase HINT1
Chains: A, B
Length: 126 amino acids
Theoretical weight: 13.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P49773 (Residues: 1-126; Coverage: 100%)
Gene names: HINT, HINT1, PKCI1, PRKCNH1
Pfam: HIT domain
Adenosine 5'-monophosphoramidase HINT1 in PDB entry 8paf, assembly 1, front view.
Adenosine 5'-monophosphoramidase HINT1 in PDB entry 8paf, assembly 1, side view.
Adenosine 5'-monophosphoramidase HINT1 in PDB entry 8paf, assembly 1, top view.
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