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Cryo EM structure of the type 3D polymorph of alpha-synuclein E46K mutant at low pH.

Electron Microscopy
2.31Å resolution
PDB entry 8pjo coloured by chain, front view.
PDB entry 8pjo coloured by chain, side view.
PDB entry 8pjo coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo decamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Alpha-synuclein
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Multimeric state: homo decamer
Accessible surface area: 26232.56 Å2
Buried surface area: 41001.17 Å2
Dissociation area: 475.78 Å2
Dissociation energy (ΔGdiss): -21.35 kcal/mol
Dissociation entropy (TΔSdiss): 12.66 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153502

Macromolecules

Alpha-synuclein
Chains: A, B, C, D, E, F, G, H, I, J
Length: 140 amino acids
Theoretical weight: 14.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37840 (Residues: 1-140; Coverage: 100%)
Gene names: NACP, PARK1, SNCA
Pfam: Synuclein
Alpha-synuclein in PDB entry 8pjo, assembly 1, front view.
Alpha-synuclein in PDB entry 8pjo, assembly 1, side view.
Alpha-synuclein in PDB entry 8pjo, assembly 1, top view.
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