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Cryo EM structure of the type 1m polymorph of alpha-synuclein

Electron Microscopy
3.26Å resolution
PDB entry 8pk2 coloured by chain, front view.
PDB entry 8pk2 coloured by chain, side view.
PDB entry 8pk2 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo pentamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Alpha-synuclein
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Multimeric state: homo pentamer
Accessible surface area: 14460.46 Å2
Buried surface area: 21854.31 Å2
Dissociation area: 10,927.16 Å2
Dissociation energy (ΔGdiss): 158.64 kcal/mol
Dissociation entropy (TΔSdiss): 47.56 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153509

Macromolecules

Alpha-synuclein
Chains: A, B, C, D, E
Length: 140 amino acids
Theoretical weight: 14.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37840 (Residues: 1-140; Coverage: 100%)
Gene names: NACP, PARK1, SNCA
Pfam: Synuclein
Alpha-synuclein in PDB entry 8pk2, assembly 1, front view.
Alpha-synuclein in PDB entry 8pk2, assembly 1, side view.
Alpha-synuclein in PDB entry 8pk2, assembly 1, top view.
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