› 8pmd

Electron Microscopy
2.95Å resolution

Nucleotide-bound BSEP in nanodiscs

Released:
DOI: 10.2210/pdb8pmd/pdb
PDB entry 8pmd coloured by chain, front view.
PDB entry 8pmd coloured by chain, side view.
PDB entry 8pmd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP.
Liu H, Irobalieva RN, Kowal J, Ni D, Nosol K, Bang-Sørensen R, Lancien L, Stahlberg H, Stieger B, Locher KP
OpenAccess logo Nat Commun 14 7296 (2023)
PMID: 37949847
Related structures: EMD-17759

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131895 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bile salt export pump Chain: A
Molecule details ›
Chain: A
Length: 1321 amino acids
Theoretical weight: 146.56 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O95342 (Residues: 1-1321; Coverage: 100%)
Gene names: ABCB11, BSEP
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand ATP 2 x ATP
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.95Å
Relevant EMDB volumes: EMD-17759
Expression system: Homo sapiens

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