Structure analysis

Structure of human KCTD15 BTB domain mutant G88D crystal form 2

X-ray diffraction
1.94Å resolution
Source organism: Homo sapiens
Assembly composition:
homo hexamer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo hexamer
Accessible surface area: 29132.87 Å2
Buried surface area: 6205.57 Å2
Dissociation area: 3,102.78 Å2
Dissociation energy (ΔGdiss): -17.47 kcal/mol
Dissociation entropy (TΔSdiss): 57.62 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-275278
Assembly 2
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Multimeric state: homo hexamer
Accessible surface area: 28893.87 Å2
Buried surface area: 6280.99 Å2
Dissociation area: 3,140.5 Å2
Dissociation energy (ΔGdiss): -14.12 kcal/mol
Dissociation entropy (TΔSdiss): 57.46 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-275278

Macromolecules

Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 116 amino acids
Theoretical weight: 13.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96SI1 (Residues: 52-165; Coverage: 40%)
Gene name: KCTD15
Pfam: BTB/POZ domain

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