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Electron Microscopy
4.2Å resolution

Cytoplasmic dynein-1 motor domain bound to dynactin-p150glued and LIS1

Released:
Source organisms:
Related structures: EMD-17826

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero nonamer (preferred)
PDBe Complex ID:
PDB-CPX-242098 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Platelet-activating factor acetylhydrolase IB subunit beta Chains: B, C, D, E
Molecule details ›
Chains: B, C, D, E
Length: 410 amino acids
Theoretical weight: 46.71 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P43034 (Residues: 1-410; Coverage: 100%)
Gene names: LIS1, MDCR, MDS, PAFAH1B1, PAFAHA
Sequence domains:
Dynactin subunit 1 Chains: F, G
Molecule details ›
Chains: F, G
Length: 1281 amino acids
Theoretical weight: 142.02 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A287B8J2 (Residues: 1-1281; Coverage: 100%)
Gene name: DCTN1
Sequence domains:
Cytoplasmic dynein 1 intermediate chain 2 Chains: H, I
Molecule details ›
Chains: H, I
Length: 612 amino acids
Theoretical weight: 68.44 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q13409 (Residues: 1-638; Coverage: 96%)
Gene names: DNCI2, DNCIC2, DYNC1I2
Sequence domains:

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.2Å
Relevant EMDB volumes: EMD-17826
Expression system: Spodoptera frugiperda