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Cryo-EM structure of the yeast fatty acid synthase at 1.9 angstrom resolution

Source organism: Saccharomyces cerevisiae
Biochemical function: transferase activity
Biological process: long-chain fatty acid biosynthetic process
Cellular component: fatty acid synthase complex

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EC 2.3.1.86: Fatty-acyl-CoA synthase system

Reaction catalysed:
Acetyl-CoA + n malonyl-CoA + 2n NADPH = long-chain-acyl-CoA + n CoA + n CO(2) + 2n NADP(+)
Systematic name:
Acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl- reducing)
Alternative Name(s):
  • FAS1 (gene name)
  • FAS2 (gene name)
  • Fatty-acyl-CoA synthase
  • Yeast fatty acid synthase

EC 4.2.1.59: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase

Reaction catalysed:
A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H(2)O
Systematic name:
(3R)-3-hydroxyoctanoyl-[acyl-carrier protein] hydro-lyase (trans-2-enoyl-[acyl-carrier protein]-forming)
Alternative Name(s):
  • (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase
  • (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase (oct-2-enoyl-[acyl-carrier protein]-forming)
  • 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase
  • Beta-hydroxyoctanoyl thioester dehydratase
  • Beta-hydroxyoctanoyl-ACP-dehydrase
  • Beta-hydroxyoctanoyl-acyl carrier protein dehydrase
  • D-3-hydroxyoctanoyl-[acyl carrier protein] dehydratase
  • FabA (gene name)
  • FabZ (gene name)

EC 3.1.2.14: Oleoyl-[acyl-carrier-protein] hydrolase

Reaction catalysed:
Oleoyl-[acyl-carrier-protein] + H(2)O = [acyl-carrier-protein] + oleate
Systematic name:
Oleoyl-[acyl-carrier-protein] hydrolase
Alternative Name(s):
  • Acyl-ACP-hydrolase
  • Acyl-[acyl-carrier-protein] hydrolase
  • Acyl-acyl carrier protein hydrolase
  • Oleoyl-ACP thioesterase
  • Oleoyl-acyl carrier protein thioesterase
  • S-acyl fatty acid synthase thioesterase

EC 2.3.1.39: [Acyl-carrier-protein] S-malonyltransferase

Reaction catalysed:
Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein]
Systematic name:
Malonyl-CoA:[acyl-carrier protein] S-malonyltransferase
Alternative Name(s):
  • Acyl carrier protein malonyltransferase
  • FabD
  • MAT
  • MCAT
  • Malonyl coenzyme A-acyl carrier protein transacylase
  • Malonyl transacylase
  • Malonyl transferase
  • Malonyl-CoA-acyl carrier protein transacylase
  • Malonyl-CoA/dephospho-CoA acyltransferase
  • Malonyl-CoA:ACP transacylase
  • Malonyl-CoA:ACP-SH transacylase
  • Malonyl-CoA:AcpM transacylase
  • Malonyl-CoA:[acyl-carrier-protein] S-malonyltransferase
  • Malonyl-CoA:acyl carrier protein transacylase
  • Malonyl-CoA:acyl-carrier-protein transacylase
  • MdcH
  • [Acyl carrier protein]malonyltransferase

EC 2.3.1.38: [Acyl-carrier-protein] S-acetyltransferase

Reaction catalysed:
Acetyl-CoA + [acyl-carrier-protein] = CoA + acetyl-[acyl-carrier-protein]
Systematic name:
Acetyl-CoA:[acyl-carrier-protein] S-acetyltransferase
Alternative Name(s):
  • ACP acetyltransferase
  • Acetyl coenzyme A-acyl-carrier-protein transacylase
  • Acyl-carrier-protein acetyltransferase
  • [ACP]-acetyltransferase
  • [Acyl-carrier protein]-acetyltransferase

EC 1.3.1.9: Enoyl-[acyl-carrier-protein] reductase (NADH)

Reaction catalysed:
An acyl-[acyl-carrier protein] + NAD(+) = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH
Systematic name:
Acyl-[acyl-carrier protein]:NAD(+) oxidoreductase
Alternative Name(s):
  • Acyl-[acyl-carrier-protein]:NAD(+) oxidoreductase
  • Enoyl-ACP reductase
  • Enoyl-[acyl carrier protein] reductase
  • FabI (gene name)
  • InhA (gene name)
  • NADH-enoyl acyl carrier protein reductase
  • NADH-specific enoyl-ACP reductase

EC 2.3.1.41: Beta-ketoacyl-[acyl-carrier-protein] synthase I

Reaction catalysed:
Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein]
Systematic name:
Acyl-[acyl-carrier protein]:malonyl-[acyl-carrier protein] C-acyltransferase (decarboxylating)
Alternative Name(s):
  • 3-ketoacyl-acyl carrier protein synthase
  • 3-oxoacyl-[acyl-carrier-protein] synthase
  • 3-oxoacyl:ACP synthase I
  • Acyl-[acyl-carrier-protein]:malonyl-[acyl-carrier-protein] C-acyltransferase (decarboxylating)
  • Acyl-malonyl acyl carrier protein-condensing enzyme
  • Acyl-malonyl(acyl-carrier-protein)-condensing enzyme
  • Beta-ketoacyl acyl carrier protein synthase
  • Beta-ketoacyl synthetase
  • Beta-ketoacyl-ACP synthase I
  • Beta-ketoacyl-ACP synthetase
  • Beta-ketoacyl-[acyl carrier protein] synthase
  • Beta-ketoacyl-acyl carrier protein synthetase
  • Beta-ketoacylsynthase
  • Condensing enzyme
  • FabB
  • FabF1
  • Fatty acid condensing enzyme
  • KAS I
  • KASI

EC 1.1.1.100: 3-oxoacyl-[acyl-carrier-protein] reductase

Reaction catalysed:
(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl-carrier-protein] + NADPH
Systematic name:
(3R)-3-hydroxyacyl-[acyl-carrier-protein]:NADP(+) oxidoreductase
Alternative Name(s):
  • 3-ketoacyl acyl carrier protein reductase
  • 3-oxoacyl-[ACP]reductase
  • Beta-ketoacyl acyl carrier protein (ACP) reductase
  • Beta-ketoacyl reductase
  • Beta-ketoacyl thioester reductase
  • Beta-ketoacyl-ACP reductase
  • Beta-ketoacyl-[acyl-carrier protein](ACP) reductase
  • Beta-ketoacyl-acyl carrier protein reductase
  • NADPH-specific 3-oxoacyl-[acylcarrier protein]reductase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00698
Domain description: Acyl transferase domain
Occurring in:
  1. Fatty acid synthase subunit beta
The deposited structure of PDB entry 8prw contains 6 copies of Pfam domain PF00698 (Acyl transferase domain) in Fatty acid synthase subunit beta. Showing 1 copy in chain B [auth G].

PF01575
Domain description: MaoC like domain
Occurring in:
  1. Fatty acid synthase subunit beta
The deposited structure of PDB entry 8prw contains 6 copies of Pfam domain PF01575 (MaoC like domain) in Fatty acid synthase subunit beta. Showing 1 copy in chain B [auth G].

PF22235
Domain description: Fatty acid synthase subunit beta, insertion domain
Occurring in:
  1. Fatty acid synthase subunit beta

PF13452
Domain description: N-terminal half of MaoC dehydratase
Occurring in:
  1. Fatty acid synthase subunit beta
The deposited structure of PDB entry 8prw contains 6 copies of Pfam domain PF13452 (N-terminal half of MaoC dehydratase) in Fatty acid synthase subunit beta. Showing 1 copy in chain B [auth G].

PF17951
Domain description: Fatty acid synthase meander beta sheet domain
Occurring in:
  1. Fatty acid synthase subunit beta
The deposited structure of PDB entry 8prw contains 6 copies of Pfam domain PF17951 (Fatty acid synthase meander beta sheet domain) in Fatty acid synthase subunit beta. Showing 1 copy in chain B [auth G].

PF08354
Domain description: Fatty acid synthase subunit beta/Fas1-like, helical
Occurring in:
  1. Fatty acid synthase subunit beta
The deposited structure of PDB entry 8prw contains 6 copies of Pfam domain PF08354 (Fatty acid synthase subunit beta/Fas1-like, helical) in Fatty acid synthase subunit beta. Showing 1 copy in chain B [auth G].

PF16073
Domain description: Starter unit:ACP transacylase in aflatoxin biosynthesis
Occurring in:
  1. Fatty acid synthase subunit beta
The deposited structure of PDB entry 8prw contains 6 copies of Pfam domain PF16073 (Starter unit:ACP transacylase in aflatoxin biosynthesis) in Fatty acid synthase subunit beta. Showing 1 copy in chain B [auth G].

PF17828
Domain description: N-terminal domain in fatty acid synthase subunit beta
Occurring in:
  1. Fatty acid synthase subunit beta
The deposited structure of PDB entry 8prw contains 6 copies of Pfam domain PF17828 (N-terminal domain in fatty acid synthase subunit beta) in Fatty acid synthase subunit beta. Showing 1 copy in chain B [auth G].

PF01648
Domain description: 4'-phosphopantetheinyl transferase superfamily
Occurring in:
  1. Fatty acid synthase subunit alpha
The deposited structure of PDB entry 8prw contains 6 copies of Pfam domain PF01648 (4'-phosphopantetheinyl transferase superfamily) in Fatty acid synthase subunit alpha. Showing 1 copy in chain A.

PF02801
Domain description: Beta-ketoacyl synthase, C-terminal domain
Occurring in:
  1. Fatty acid synthase subunit alpha
The deposited structure of PDB entry 8prw contains 6 copies of Pfam domain PF02801 (Beta-ketoacyl synthase, C-terminal domain) in Fatty acid synthase subunit alpha. Showing 1 copy in chain A.

PF00109
Domain description: Beta-ketoacyl synthase, N-terminal domain
Occurring in:
  1. Fatty acid synthase subunit alpha
The deposited structure of PDB entry 8prw contains 6 copies of Pfam domain PF00109 (Beta-ketoacyl synthase, N-terminal domain) in Fatty acid synthase subunit alpha. Showing 1 copy in chain A.

PF18314
Domain description: Fatty acid synthase type I helical domain
Occurring in:
  1. Fatty acid synthase subunit alpha
The deposited structure of PDB entry 8prw contains 6 copies of Pfam domain PF18314 (Fatty acid synthase type I helical domain ) in Fatty acid synthase subunit alpha. Showing 1 copy in chain A.

PF18325
Domain description: Fatty acid synthase subunit alpha Acyl carrier domain
Occurring in:
  1. Fatty acid synthase subunit alpha
The deposited structure of PDB entry 8prw contains 6 copies of Pfam domain PF18325 (Fatty acid synthase subunit alpha Acyl carrier domain) in Fatty acid synthase subunit alpha. Showing 1 copy in chain A (this domain is out of the observed residue ranges!).

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