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Tilapia Lake Virus polymerase in vRNA initiation state (transcriptase conformation)

Electron Microscopy
2.73Å resolution
PDB entry 8psn coloured by chain, front view.
PDB entry 8psn coloured by chain, side view.
PDB entry 8psn coloured by chain, top view.
Source organism: Tilapia lake virus
Assembly composition:
hetero hexamer (preferred)
Entry contents: 3 distinct polypeptide molecules
1 distinct DNA molecule
1 distinct RNA molecule

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero hexamer
Accessible surface area: 58114.74 Å2
Buried surface area: 29514.72 Å2
Dissociation area: 1,430.3 Å2
Dissociation energy (ΔGdiss): 9.07 kcal/mol
Dissociation entropy (TΔSdiss): 10.87 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-268805

Macromolecules

Polymerase acidic protein (PA-like)
Chain: A
Length: 419 amino acids
Theoretical weight: 47.78 KDa
Source organism: Tilapia lake virus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A0A142I7Z3 (Residues: 1-419; Coverage: 100%)
Polymerase acidic protein (PA-like) in PDB entry 8psn, assembly 1, front view.
Polymerase acidic protein (PA-like) in PDB entry 8psn, assembly 1, side view.
Polymerase acidic protein (PA-like) in PDB entry 8psn, assembly 1, top view.
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Putative PB1
Chain: B
Length: 519 amino acids
Theoretical weight: 57.18 KDa
Source organism: Tilapia lake virus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A0A1Y9SHW4 (Residues: 1-519; Coverage: 100%)
Gene name: PB1
Putative PB1 in PDB entry 8psn, assembly 1, front view.
Putative PB1 in PDB entry 8psn, assembly 1, side view.
Putative PB1 in PDB entry 8psn, assembly 1, top view.
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RNA-dependent RNA polymerase
Chain: C
Length: 478 amino acids
Theoretical weight: 53.78 KDa
Source organism: Tilapia lake virus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A0A7G3S745 (Residues: 1-457; Coverage: 100%)
RNA-dependent RNA polymerase in PDB entry 8psn, assembly 1, front view.
RNA-dependent RNA polymerase in PDB entry 8psn, assembly 1, side view.
RNA-dependent RNA polymerase in PDB entry 8psn, assembly 1, top view.
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DNA chain E
Name: DNA (5'-D(*(CTP))-3')
Representative chains: E
Length: 1 nucleotides
Theoretical weight: 483 Da
DNA (5'-D(*(CTP))-3') in PDB entry 8psn, assembly 1, front view.
DNA (5'-D(*(CTP))-3') in PDB entry 8psn, assembly 1, side view.
DNA (5'-D(*(CTP))-3') in PDB entry 8psn, assembly 1, top view.
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RNA chains S, V
Name: 5' vRNA end - vRNA loop (40-mer)
Representative chains: S, V
Length: 40 nucleotides
Theoretical weight: 12.74 KDa
5' vRNA end - vRNA loop (40-mer) in PDB entry 8psn, assembly 1, front view.
5' vRNA end - vRNA loop (40-mer) in PDB entry 8psn, assembly 1, side view.
5' vRNA end - vRNA loop (40-mer) in PDB entry 8psn, assembly 1, top view.
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