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Tilapia Lake Virus polymerase in vRNA elongation state (transcriptase conformation)

Electron Microscopy
2.96Å resolution
PDB entry 8psx coloured by chain, front view.
PDB entry 8psx coloured by chain, side view.
PDB entry 8psx coloured by chain, top view.
Source organism: Tilapia lake virus
Assembly composition:
hetero hexamer (preferred)
Entry contents: 3 distinct polypeptide molecules
2 distinct RNA molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero hexamer
Accessible surface area: 59180.56 Å2
Buried surface area: 29413.15 Å2
Dissociation area: 1,018.06 Å2
Dissociation energy (ΔGdiss): 3.05 kcal/mol
Dissociation entropy (TΔSdiss): 9.27 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-237493

Macromolecules

Polymerase acidic protein (PA-like)
Chain: A
Length: 419 amino acids
Theoretical weight: 47.78 KDa
Source organism: Tilapia lake virus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A0A142I7Z3 (Residues: 1-419; Coverage: 100%)
Polymerase acidic protein (PA-like) in PDB entry 8psx, assembly 1, front view.
Polymerase acidic protein (PA-like) in PDB entry 8psx, assembly 1, side view.
Polymerase acidic protein (PA-like) in PDB entry 8psx, assembly 1, top view.
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Putative PB1
Chain: B
Length: 519 amino acids
Theoretical weight: 57.18 KDa
Source organism: Tilapia lake virus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A0A1Y9SHW4 (Residues: 1-519; Coverage: 100%)
Gene name: PB1
Putative PB1 in PDB entry 8psx, assembly 1, front view.
Putative PB1 in PDB entry 8psx, assembly 1, side view.
Putative PB1 in PDB entry 8psx, assembly 1, top view.
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RNA-dependent RNA polymerase
Chain: C
Length: 478 amino acids
Theoretical weight: 53.78 KDa
Source organism: Tilapia lake virus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A0A7G3S745 (Residues: 1-457; Coverage: 100%)
RNA-dependent RNA polymerase in PDB entry 8psx, assembly 1, front view.
RNA-dependent RNA polymerase in PDB entry 8psx, assembly 1, side view.
RNA-dependent RNA polymerase in PDB entry 8psx, assembly 1, top view.
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RNA chains S, V
Name: 5' vRNA end - vRNA loop (40-mer)
Representative chains: S, V
Length: 40 nucleotides
Theoretical weight: 12.74 KDa
5' vRNA end - vRNA loop (40-mer) in PDB entry 8psx, assembly 1, front view.
5' vRNA end - vRNA loop (40-mer) in PDB entry 8psx, assembly 1, side view.
5' vRNA end - vRNA loop (40-mer) in PDB entry 8psx, assembly 1, top view.
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RNA chain P
Name: Transcription-like product
Representative chains: P
Length: 21 nucleotides
Theoretical weight: 6.68 KDa
Transcription-like product in PDB entry 8psx, assembly 1, front view.
Transcription-like product in PDB entry 8psx, assembly 1, side view.
Transcription-like product in PDB entry 8psx, assembly 1, top view.
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