› › Structure analysis

LSD1 Y391K-CoREST bound to Acetylated K14 of Histone H3

X-ray diffraction
2.87Å resolution
PDB entry 8q1j coloured by chain, front view.
PDB entry 8q1j coloured by chain, side view.
PDB entry 8q1j coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 37071.51 Å2
Buried surface area: 8922.81 Å2
Dissociation area: 2,662.84 Å2
Dissociation energy (ΔGdiss): 34.65 kcal/mol
Dissociation entropy (TΔSdiss): 13.85 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-244373

Macromolecules

Lysine-specific histone demethylase 1A
Chain: A
Length: 730 amino acids
Theoretical weight: 81.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O60341 (Residues: 123-852; Coverage: 86%)
Gene names: AOF2, KDM1, KDM1A, KIAA0601, LSD1
Pfam:
Lysine-specific histone demethylase 1A in PDB entry 8q1j, assembly 1, front view.
Lysine-specific histone demethylase 1A in PDB entry 8q1j, assembly 1, side view.
Lysine-specific histone demethylase 1A in PDB entry 8q1j, assembly 1, top view.
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REST corepressor 1
Chain: B
Length: 178 amino acids
Theoretical weight: 20.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9UKL0 (Residues: 308-485; Coverage: 37%)
Gene names: KIAA0071, RCOR, RCOR1
Pfam:
REST corepressor 1 in PDB entry 8q1j, assembly 1, front view.
REST corepressor 1 in PDB entry 8q1j, assembly 1, side view.
REST corepressor 1 in PDB entry 8q1j, assembly 1, top view.
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Histone H3.3C
Chain: C
Length: 21 amino acids
Theoretical weight: 2.3 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q6NXT2 (Residues: 2-22; Coverage: 16%)
Gene names: H3-5, H3F3C
Histone H3.3C in PDB entry 8q1j, assembly 1, front view.
Histone H3.3C in PDB entry 8q1j, assembly 1, side view.
Histone H3.3C in PDB entry 8q1j, assembly 1, top view.
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