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Crystal structure of YTHDC1 in complex with Compound 19 (ZA_347)

X-ray diffraction
1.42Å resolution
PDB entry 8q38 coloured by chain, front view.
PDB entry 8q38 coloured by chain, side view.
PDB entry 8q38 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: YTH domain-containing protein 1
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Multimeric state: monomeric
Accessible surface area: 8308.78 Å2
Buried surface area: 684.6 Å2
Dissociation area: 73.92 Å2
Dissociation energy (ΔGdiss): 10.45 kcal/mol
Dissociation entropy (TΔSdiss): 0.58 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-188634
Assembly 2
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Assembly Name: YTH domain-containing protein 1
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Multimeric state: monomeric
Accessible surface area: 8266.76 Å2
Buried surface area: 794.4 Å2
Dissociation area: 52.67 Å2
Dissociation energy (ΔGdiss): 5.89 kcal/mol
Dissociation entropy (TΔSdiss): 0.58 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-188634

Macromolecules

YTH domain-containing protein 1
Chains: A, B
Length: 166 amino acids
Theoretical weight: 18.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96MU7 (Residues: 345-509; Coverage: 23%)
Gene names: KIAA1966, YT521, YTHDC1
Pfam: YT521-B-like domain
YTH domain-containing protein 1 in PDB entry 8q38, assembly 1, front view.
YTH domain-containing protein 1 in PDB entry 8q38, assembly 1, side view.
YTH domain-containing protein 1 in PDB entry 8q38, assembly 1, top view.
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