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PKR kinase domain- eIF2alpha in complex with compound

X-ray diffraction
2.451Å resolution
PDB entry 8qel coloured by chain, front view.
PDB entry 8qel coloured by chain, side view.
PDB entry 8qel coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Interferon-induced, double-stranded RNA-activated protein kinase and Eukaryotic translation initiation factor 2 subunit alpha
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Multimeric state: hetero dimer
Accessible surface area: 21912.75 Å2
Buried surface area: 1075.96 Å2
Dissociation area: 537.98 Å2
Dissociation energy (ΔGdiss): -2.95 kcal/mol
Dissociation entropy (TΔSdiss): 12.14 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-228501

Macromolecules

Eukaryotic translation initiation factor 2 subunit alpha
Chain: A
Length: 173 amino acids
Theoretical weight: 20.41 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P20459 (Residues: 4-176; Coverage: 57%)
Gene names: J1429, SUI2, TIF211, YJR007W
Pfam:
Eukaryotic translation initiation factor 2 subunit alpha in PDB entry 8qel, assembly 1, front view.
Eukaryotic translation initiation factor 2 subunit alpha in PDB entry 8qel, assembly 1, side view.
Eukaryotic translation initiation factor 2 subunit alpha in PDB entry 8qel, assembly 1, top view.
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Interferon-induced, double-stranded RNA-activated protein kinase
Chain: B
Length: 273 amino acids
Theoretical weight: 31.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19525 (Residues: 258-337, 344-541; Coverage: 48%)
Gene names: EIF2AK2, PKR, PRKR
Pfam: Protein kinase domain
Interferon-induced, double-stranded RNA-activated protein kinase in PDB entry 8qel, assembly 1, front view.
Interferon-induced, double-stranded RNA-activated protein kinase in PDB entry 8qel, assembly 1, side view.
Interferon-induced, double-stranded RNA-activated protein kinase in PDB entry 8qel, assembly 1, top view.
Molecule details ›

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