› 8qn6

Electron Microscopy
2.4Å resolution

Amyloid-beta 40 type 2 filament from the leptomeninges of individual with Alzheimer's disease and cerebral amyloid angiopathy

Released:
DOI: 10.2210/pdb8qn6/pdb
PDB entry 8qn6 coloured by chain, front view.
PDB entry 8qn6 coloured by chain, side view.
PDB entry 8qn6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of Aβ40 filaments from the leptomeninges of individuals with Alzheimer's disease and cerebral amyloid angiopathy.
Yang Y, Murzin AG, Peak-Chew S, Franco C, Garringer HJ, Newell KL, Ghetti B, Goedert M, Scheres SHW
OpenAccess logo Acta Neuropathol Commun 11 191 (2023)
PMID: 38049918
Related structures: EMD-18508

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
homo 22-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-272315 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amyloid-beta protein 40 Chains: A, F
Molecule details ›
Chains: A, F
Length: 40 amino acids
Theoretical weight: 4.34 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P05067 (Residues: 672-711; Coverage: 5%)
Gene names: A4, AD1, APP
Sequence domains: Beta-amyloid peptide (beta-APP)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.4Å
Relevant EMDB volumes: EMD-18508

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