› › Structure analysis

Amyloid-beta 40 type 2 filament from the leptomeninges of individual with Alzheimer's disease and cerebral amyloid angiopathy

Electron Microscopy
2.4Å resolution
PDB entry 8qn6 coloured by chain, front view.
PDB entry 8qn6 coloured by chain, side view.
PDB entry 8qn6 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo 22-mer (preferred)
Entry contents: 1 distinct polypeptide molecule

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Soluble APP-beta
hide full assembly name
Multimeric state: homo 22-mer
Accessible surface area: 26540.84 Å2
Buried surface area: 26498.83 Å2
Dissociation area: 288.61 Å2
Dissociation energy (ΔGdiss): -12.16 kcal/mol
Dissociation entropy (TΔSdiss): 12.82 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-272315

Macromolecules

Amyloid-beta protein 40
Chains: A, F
Length: 40 amino acids
Theoretical weight: 4.34 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P05067 (Residues: 672-711; Coverage: 5%)
Gene names: A4, AD1, APP
Pfam: Beta-amyloid peptide (beta-APP)
Amyloid-beta A4 protein in PDB entry 8qn6, assembly 1, front view.
Amyloid-beta A4 protein in PDB entry 8qn6, assembly 1, side view.
Amyloid-beta A4 protein in PDB entry 8qn6, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links