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Crystal structure of the complex between DMC1 and the PhePP domain of BRCA2

X-ray diffraction
3.461Å resolution
PDB entry 8qqe coloured by chain, front view.
PDB entry 8qqe coloured by chain, side view.
PDB entry 8qqe coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero hexadecamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Breast cancer type 2 susceptibility protein and Meiotic recombination protein DMC1/LIM15 homolog
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Multimeric state: hetero hexadecamer
Accessible surface area: 96044.71 Å2
Buried surface area: 30806.1 Å2
Dissociation area: 1,170.89 Å2
Dissociation energy (ΔGdiss): -0.35 kcal/mol
Dissociation entropy (TΔSdiss): 21.76 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-246056

Macromolecules

Meiotic recombination protein DMC1/LIM15 homolog
Chains: A, B
Length: 340 amino acids
Theoretical weight: 37.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14565 (Residues: 2-340; Coverage: 100%)
Gene names: DMC1, DMC1H, LIM15
Pfam:
Meiotic recombination protein DMC1/LIM15 homolog in PDB entry 8qqe, assembly 1, front view.
Meiotic recombination protein DMC1/LIM15 homolog in PDB entry 8qqe, assembly 1, side view.
Meiotic recombination protein DMC1/LIM15 homolog in PDB entry 8qqe, assembly 1, top view.
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Breast cancer type 2 susceptibility protein
Chains: C, D
Length: 20 amino acids
Theoretical weight: 2.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli #1/H766
UniProt:
  • Canonical: P51587 (Residues: 2398-2417; Coverage: 1%)
Gene names: BRCA2, FACD, FANCD1
Breast cancer type 2 susceptibility protein in PDB entry 8qqe, assembly 1, front view.
Breast cancer type 2 susceptibility protein in PDB entry 8qqe, assembly 1, side view.
Breast cancer type 2 susceptibility protein in PDB entry 8qqe, assembly 1, top view.
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