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Structure of p53 cancer mutant Y126C

X-ray diffraction
1.69Å resolution
PDB entry 8qwk coloured by chain, front view.
PDB entry 8qwk coloured by chain, side view.
PDB entry 8qwk coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cellular tumor antigen p53
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Multimeric state: monomeric
Accessible surface area: 9710.14 Å2
Buried surface area: 179.45 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138105

Macromolecules

Cellular tumor antigen p53
Chain: A
Length: 219 amino acids
Theoretical weight: 24.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04637 (Residues: 94-312; Coverage: 56%)
Gene names: P53, TP53
Pfam: P53 DNA-binding domain
Cellular tumor antigen p53 in PDB entry 8qwk, assembly 1, front view.
Cellular tumor antigen p53 in PDB entry 8qwk, assembly 1, side view.
Cellular tumor antigen p53 in PDB entry 8qwk, assembly 1, top view.
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