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Cryo-EM structure of tetrameric human SAMHD1 State II - Hemi-relaxed

Electron Microscopy
2.82Å resolution
PDB entry 8qxl coloured by chain, front view.
PDB entry 8qxl coloured by chain, side view.
PDB entry 8qxl coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
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Multimeric state: homo tetramer
Accessible surface area: 72652.9 Å2
Buried surface area: 26316.56 Å2
Dissociation area: 3,642.31 Å2
Dissociation energy (ΔGdiss): 8.87 kcal/mol
Dissociation entropy (TΔSdiss): 16.52 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-195223

Macromolecules

Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
Chains: A, B, C, D
Length: 626 amino acids
Theoretical weight: 72.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y3Z3 (Residues: 1-626; Coverage: 100%)
Gene names: MOP5, SAMHD1
Pfam:
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 in PDB entry 8qxl, assembly 1, front view.
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 in PDB entry 8qxl, assembly 1, side view.
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 in PDB entry 8qxl, assembly 1, top view.
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