Function and Biology

Crystal structure of human eIF2 alpha-gamma complexed with PPP1R15A_420-452

Source organism: Homo sapiens
Biochemical function: protein binding
Biological process: translational initiation
Cellular component: extracellular exosome

EC 3.6.5.3: Protein-synthesizing GTPase

Reaction catalysed:
GTP + H(2)O = GDP + phosphate
Systematic name:
GTP phosphohydrolase (mRNA-translation-assisting)
Alternative Name(s):
  • Elongation factor (EF)
  • Initiation factor (IF)
  • Peptide-release factor (RF)
  • Peptide-release or termination factor

Sequence families

Pfam Protein families (Pfam)
PF07541
Domain description: Eukaryotic translation initiation factor 2 alpha subunit
Occurring in:
  1. Eukaryotic translation initiation factor 2 subunit 1
The deposited structure of PDB entry 8qzz contains 1 copy of Pfam domain PF07541 (Eukaryotic translation initiation factor 2 alpha subunit) in Eukaryotic translation initiation factor 2 subunit 1. Showing 1 copy in chain B.

PF00575
Domain description: S1 RNA binding domain
Occurring in:
  1. Eukaryotic translation initiation factor 2 subunit 1
The deposited structure of PDB entry 8qzz contains 1 copy of Pfam domain PF00575 (S1 RNA binding domain) in Eukaryotic translation initiation factor 2 subunit 1. Showing 1 copy in chain B (this domain is out of the observed residue ranges!).

PF09173
Domain description: Initiation factor eIF2 gamma, C terminal
Occurring in:
  1. Eukaryotic translation initiation factor 2 subunit 3
The deposited structure of PDB entry 8qzz contains 1 copy of Pfam domain PF09173 (Initiation factor eIF2 gamma, C terminal) in Eukaryotic translation initiation factor 2 subunit 3. Showing 1 copy in chain A.

PF03144
Domain description: Elongation factor Tu domain 2
Occurring in:
  1. Eukaryotic translation initiation factor 2 subunit 3
The deposited structure of PDB entry 8qzz contains 1 copy of Pfam domain PF03144 (Elongation factor Tu domain 2) in Eukaryotic translation initiation factor 2 subunit 3. Showing 1 copy in chain A.

PF00009
Domain description: Elongation factor Tu GTP binding domain
Occurring in:
  1. Eukaryotic translation initiation factor 2 subunit 3
The deposited structure of PDB entry 8qzz contains 1 copy of Pfam domain PF00009 (Elongation factor Tu GTP binding domain) in Eukaryotic translation initiation factor 2 subunit 3. Showing 1 copy in chain A.