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Structure of Integrator-PP2A-SOSS-CTD post-termination complex

Source organisms:
Biochemical function: protein binding
Biological process: regulation of transcription elongation by RNA polymerase II
Cellular component: nucleus

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EC 3.1.3.16: Protein-serine/threonine phosphatase

Reaction catalysed:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Systematic name:
Phosphoprotein phosphohydrolase
Alternative Name(s):
  • 3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase
  • Aspergillus awamori acid protein phosphatase
  • BCKDH phosphatase
  • Branched-chain alpha-keto acid dehydrogenase phosphatase
  • Calcineurin
  • Casein phosphatase
  • HMG-CoA reductase phosphatase
  • Phosphatase 2A
  • Phosphatase 2B
  • Phosphatase C-II
  • Phosphatase H-II
  • Phosphatase I
  • Phosphatase IB
  • Phosphatase II
  • Phosphatase III
  • Phosphatase IV
  • Phosphatase SP
  • Phosphoprotein phosphatase
  • Phosphopyruvate dehydrogenase phosphatase
  • Phosphospectrin phosphatase
  • Polycation modulated (PCM-) phosphatase
  • Protein D phosphatase
  • Protein phosphatase
  • Protein phosphatase-1
  • Protein phosphatase-2A
  • Protein phosphatase-2B
  • Protein phosphatase-2C
  • Serine/threonine specific protein phosphatase

EC 2.7.7.6: DNA-directed RNA polymerase

Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
Nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed)
Alternative Name(s):
  • C RNA formation factors
  • C ribonucleic acid formation factors
  • DNA-dependent RNA nucleotidyltransferase
  • DNA-dependent RNA polymerase
  • DNA-dependent ribonucleate nucleotidyltransferase
  • Deoxyribonucleic acid-dependent ribonucleic acid polymerase
  • RNA nucleotidyltransferase
  • RNA nucleotidyltransferase (DNA-directed)
  • RNA polymerase
  • RNA polymerase I
  • RNA polymerase II
  • RNA polymerase III
  • RNA transcriptase
  • Ribonucleate nucleotidyltransferase
  • Ribonucleate polymerase
  • Ribonucleic acid nucleotidyltransferase
  • Ribonucleic acid polymerase
  • Ribonucleic acid transcriptase
  • Ribonucleic polymerase
  • Ribonucleic transcriptase
  • Transcriptase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF02985
Domain description: HEAT repeat
Occurring in:
  1. Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
The deposited structure of PDB entry 8rbz contains 5 copies of Pfam domain PF02985 (HEAT repeat) in Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. Showing 5 copies in chain R [auth p].

PF10996
Domain description: Beta-Casp domain
Occurring in:
  1. Integrator complex subunit 9
  2. Integrator complex subunit 11
The deposited structure of PDB entry 8rbz contains 1 copy of Pfam domain PF10996 (Beta-Casp domain) in Integrator complex subunit 9. Showing 1 copy in chain M [auth i].
The deposited structure of PDB entry 8rbz contains 1 copy of Pfam domain PF10996 (Beta-Casp domain) in Integrator complex subunit 11. Showing 1 copy in chain O [auth k].

PF16661
Domain description: Metallo-beta-lactamase superfamily domain
Occurring in:
  1. Integrator complex subunit 9
  2. Integrator complex subunit 11
The deposited structure of PDB entry 8rbz contains 1 copy of Pfam domain PF16661 (Metallo-beta-lactamase superfamily domain) in Integrator complex subunit 9. Showing 1 copy in chain M [auth i].
The deposited structure of PDB entry 8rbz contains 1 copy of Pfam domain PF16661 (Metallo-beta-lactamase superfamily domain) in Integrator complex subunit 11. Showing 1 copy in chain O [auth k].

PF13519
Domain description: von Willebrand factor type A domain
Occurring in:
  1. Integrator complex subunit 6
  2. Integrator complex subunit 14
The deposited structure of PDB entry 8rbz contains 1 copy of Pfam domain PF13519 (von Willebrand factor type A domain) in Integrator complex subunit 6. Showing 1 copy in chain J [auth f].
The deposited structure of PDB entry 8rbz contains 1 copy of Pfam domain PF13519 (von Willebrand factor type A domain) in Integrator complex subunit 14. Showing 1 copy in chain P [auth n].

PF05001
Domain description: RNA polymerase Rpb1 C-terminal repeat
Occurring in:
  1. DNA-directed RNA polymerase subunit
The deposited structure of PDB entry 8rbz contains 1 copy of Pfam domain PF05001 (RNA polymerase Rpb1 C-terminal repeat ) in DNA-directed RNA polymerase subunit. Showing 1 copy in chain D [auth Y].

PF00149
Domain description: Calcineurin-like phosphoesterase
Occurring in:
  1. Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
The deposited structure of PDB entry 8rbz contains 1 copy of Pfam domain PF00149 (Calcineurin-like phosphoesterase) in Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform. Showing 1 copy in chain S [auth q].

PF14964
Domain description: Integrator complex subunit 15
Occurring in:
  1. Integrator complex subunit 15
The deposited structure of PDB entry 8rbz contains 1 copy of Pfam domain PF14964 (Integrator complex subunit 15) in Integrator complex subunit 15. Showing 1 copy in chain Q [auth o].

PF20504
Domain description: Integrator complex subunit 14, alpha-helical domain
Occurring in:
  1. Integrator complex subunit 14
The deposited structure of PDB entry 8rbz contains 1 copy of Pfam domain PF20504 (Integrator complex subunit 14, alpha-helical domain) in Integrator complex subunit 14. Showing 1 copy in chain P [auth n] (this domain is out of the observed residue ranges!).

PF19435
Domain description: Integrator complex subunit 14, beta-barrel domain
Occurring in:
  1. Integrator complex subunit 14
The deposited structure of PDB entry 8rbz contains 1 copy of Pfam domain PF19435 (Integrator complex subunit 14, beta-barrel domain) in Integrator complex subunit 14. Showing 1 copy in chain P [auth n] (this domain is out of the observed residue ranges!).

PF10221
Domain description: Cell cycle and development regulator Mat89Bb
Occurring in:
  1. Integrator complex subunit 13
The deposited structure of PDB entry 8rbz contains 1 copy of Pfam domain PF10221 (Cell cycle and development regulator Mat89Bb) in Integrator complex subunit 13. Showing 1 copy in chain U [auth m].

PF21386
Domain description: Integrator IntS11, C-terminal domain
Occurring in:
  1. Integrator complex subunit 11
The deposited structure of PDB entry 8rbz contains 1 copy of Pfam domain PF21386 (Integrator IntS11, C-terminal domain) in Integrator complex subunit 11. Showing 1 copy in chain O [auth k].

PF07521
Domain description: Zn-dependent metallo-hydrolase RNA specificity domain
Occurring in:
  1. Integrator complex subunit 11
The deposited structure of PDB entry 8rbz contains 1 copy of Pfam domain PF07521 (Zn-dependent metallo-hydrolase RNA specificity domain) in Integrator complex subunit 11. Showing 1 copy in chain O [auth k].

PF21045
Domain description: Integrator subunit 10
Occurring in:
  1. Integrator complex subunit 10
The deposited structure of PDB entry 8rbz contains 1 copy of Pfam domain PF21045 (Integrator subunit 10) in Integrator complex subunit 10. Showing 1 copy in chain N [auth j].

PF21382
Domain description: Integrator IntS9, C-terminal domain
Occurring in:
  1. Integrator complex subunit 9
The deposited structure of PDB entry 8rbz contains 1 copy of Pfam domain PF21382 (Integrator IntS9, C-terminal domain) in Integrator complex subunit 9. Showing 1 copy in chain M [auth i].

PF22965
Domain description: Integrator complex subunit 7, C-terminal domain
Occurring in:
  1. Integrator complex subunit 7

PF15300
Domain description: INTS6/SAGE1/DDX26B/CT45 C-terminus
Occurring in:
  1. Integrator complex subunit 6
The deposited structure of PDB entry 8rbz contains 1 copy of Pfam domain PF15300 (INTS6/SAGE1/DDX26B/CT45 C-terminus) in Integrator complex subunit 6. Showing 1 copy in chain J [auth f] (this domain is out of the observed residue ranges!).

PF14838
Domain description: Integrator complex subunit 5 C-terminus
Occurring in:
  1. Integrator complex subunit 5
The deposited structure of PDB entry 8rbz contains 1 copy of Pfam domain PF14838 (Integrator complex subunit 5 C-terminus) in Integrator complex subunit 5. Showing 1 copy in chain I [auth e].

PF14837
Domain description: Integrator complex subunit 5 N-terminus
Occurring in:
  1. Integrator complex subunit 5
The deposited structure of PDB entry 8rbz contains 1 copy of Pfam domain PF14837 (Integrator complex subunit 5 N-terminus) in Integrator complex subunit 5. Showing 1 copy in chain I [auth e].

PF13646
Domain description: HEAT repeats
Occurring in:
  1. Integrator complex subunit 4
The deposited structure of PDB entry 8rbz contains 1 copy of Pfam domain PF13646 (HEAT repeats) in Integrator complex subunit 4. Showing 1 copy in chain H [auth d].

PF20168
Domain description: Sister chromatid cohesion protein PDS5 protein
Occurring in:
  1. Integrator complex subunit 4
The deposited structure of PDB entry 8rbz contains 1 copy of Pfam domain PF20168 (Sister chromatid cohesion protein PDS5 protein) in Integrator complex subunit 4. Showing 1 copy in chain H [auth d].

PF10189
Domain description: Integrator complex subunit 3 N-terminal
Occurring in:
  1. Integrator complex subunit 3
The deposited structure of PDB entry 8rbz contains 1 copy of Pfam domain PF10189 (Integrator complex subunit 3 N-terminal ) in Integrator complex subunit 3. Showing 1 copy in chain G [auth c].

PF14750
Domain description: Integrator complex subunit 2
Occurring in:
  1. Integrator complex subunit 2
The deposited structure of PDB entry 8rbz contains 1 copy of Pfam domain PF14750 (Integrator complex subunit 2) in Integrator complex subunit 2. Showing 1 copy in chain F [auth b].

PF22928
Domain description: Integrator complex subunit 1, R4 domain
Occurring in:
  1. Integrator complex subunit 1

PF22927
Domain description: Integrator complex subunit 1, R3 domain
Occurring in:
  1. Integrator complex subunit 1

PF22929
Domain description: Integrator complex subunit 1, INTS2-binding domain
Occurring in:
  1. Integrator complex subunit 1

PF12432
Domain description: Integrator complex subunit 1, RP2B-binding domain
Occurring in:
  1. Integrator complex subunit 1
The deposited structure of PDB entry 8rbz contains 1 copy of Pfam domain PF12432 (Protein of unknown function (DUF3677) ) in Integrator complex subunit 1. Showing 1 copy in chain E [auth a] (this domain is out of the observed residue ranges!).

PF15925
Domain description: SOSS complex subunit C
Occurring in:
  1. SOSS complex subunit C
The deposited structure of PDB entry 8rbz contains 1 copy of Pfam domain PF15925 (SOSS complex subunit C) in SOSS complex subunit C. Showing 1 copy in chain C.

PF21473
Domain description: Single-stranded DNA binding protein Ssb-like, OB fold
Occurring in:
  1. SOSS complex subunit B1
The deposited structure of PDB entry 8rbz contains 1 copy of Pfam domain PF21473 (Single-stranded DNA binding protein Ssb-like, OB fold) in SOSS complex subunit B1. Showing 1 copy in chain B.

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