Function and Biology Details
Reactions catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero 21-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-239616 (preferred)
Entry contents:
21 distinct polypeptide molecules
Macromolecules (21 distinct):
UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK
Chain: 1
SOSS complex subunit B1
Chain: B
Molecule details ›
Chain: B
Length: 213 amino acids
Theoretical weight: 22.57 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: Single-stranded DNA binding protein Ssb-like, OB fold
Length: 213 amino acids
Theoretical weight: 22.57 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q9BQ15 (Residues: 1-211; Coverage: 100%)
Sequence domains: Single-stranded DNA binding protein Ssb-like, OB fold
SOSS complex subunit C
Chain: C
Molecule details ›
Chain: C
Length: 106 amino acids
Theoretical weight: 11.64 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: SOSS complex subunit C
Length: 106 amino acids
Theoretical weight: 11.64 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q9NRY2 (Residues: 1-104; Coverage: 100%)
Sequence domains: SOSS complex subunit C
DNA-directed RNA polymerase subunit
Chain: Y
Molecule details ›
Chain: Y
Length: 13 amino acids
Theoretical weight: 1.36 KDa
Source organism: Sus scrofa
UniProt:
Sequence domains: RNA polymerase Rpb1 C-terminal repeat
Length: 13 amino acids
Theoretical weight: 1.36 KDa
Source organism: Sus scrofa
UniProt:
- Canonical:
I3LJR4 (Residues: 1792-1804; Coverage: 1%)
Sequence domains: RNA polymerase Rpb1 C-terminal repeat
Integrator complex subunit 1
Chain: a
Molecule details ›
Chain: a
Length: 2192 amino acids
Theoretical weight: 244.78 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Length: 2192 amino acids
Theoretical weight: 244.78 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q8N201 (Residues: 1-2190; Coverage: 100%)
Sequence domains:
Integrator complex subunit 2
Chain: b
Molecule details ›
Chain: b
Length: 1204 amino acids
Theoretical weight: 134.45 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: Integrator complex subunit 2
Length: 1204 amino acids
Theoretical weight: 134.45 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q9H0H0 (Residues: 1-1204; Coverage: 100%)
Sequence domains: Integrator complex subunit 2
Integrator complex subunit 3
Chain: c
Molecule details ›
Chain: c
Length: 1042 amino acids
Theoretical weight: 118.16 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: Integrator complex subunit 3 N-terminal
Length: 1042 amino acids
Theoretical weight: 118.16 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q68E01 (Residues: 1-1043; Coverage: 100%)
Sequence domains: Integrator complex subunit 3 N-terminal
Integrator complex subunit 4
Chain: d
Molecule details ›
Chain: d
Length: 963 amino acids
Theoretical weight: 108.31 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Length: 963 amino acids
Theoretical weight: 108.31 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q96HW7 (Residues: 1-963; Coverage: 100%)
Sequence domains:
Integrator complex subunit 5
Chain: e
Molecule details ›
Chain: e
Length: 1021 amino acids
Theoretical weight: 108.32 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia
UniProt:
Sequence domains:
Length: 1021 amino acids
Theoretical weight: 108.32 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia
UniProt:
- Canonical:
Q6P9B9 (Residues: 1-1019; Coverage: 100%)
Sequence domains:
Integrator complex subunit 6
Chain: f
Molecule details ›
Integrator complex subunit 7
Chain: g
Molecule details ›
Chain: g
Length: 964 amino acids
Theoretical weight: 107.15 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: Integrator complex subunit 7, C-terminal domain
Length: 964 amino acids
Theoretical weight: 107.15 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q9NVH2 (Residues: 1-962; Coverage: 100%)
Sequence domains: Integrator complex subunit 7, C-terminal domain
Integrator complex subunit 8
Chain: h
Molecule details ›
Chain: h
Length: 995 amino acids
Theoretical weight: 113.22 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Length: 995 amino acids
Theoretical weight: 113.22 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q75QN2 (Residues: 1-995; Coverage: 100%)
Integrator complex subunit 9
Chain: i
Molecule details ›
Chain: i
Length: 658 amino acids
Theoretical weight: 73.89 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Length: 658 amino acids
Theoretical weight: 73.89 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q9NV88 (Residues: 1-658; Coverage: 100%)
Sequence domains:
Integrator complex subunit 10
Chain: j
Molecule details ›
Chain: j
Length: 710 amino acids
Theoretical weight: 82.34 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: Integrator subunit 10
Length: 710 amino acids
Theoretical weight: 82.34 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q9NVR2 (Residues: 1-710; Coverage: 100%)
Sequence domains: Integrator subunit 10
Integrator complex subunit 11
Chain: k
Molecule details ›
Chain: k
Length: 602 amino acids
Theoretical weight: 67.97 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Length: 602 amino acids
Theoretical weight: 67.97 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q5TA45 (Residues: 1-600; Coverage: 100%)
Sequence domains:
Integrator complex subunit 14
Chain: n
Molecule details ›
Chain: n
Length: 518 amino acids
Theoretical weight: 57.53 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Length: 518 amino acids
Theoretical weight: 57.53 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q96SY0 (Residues: 1-518; Coverage: 100%)
Sequence domains:
Integrator complex subunit 15
Chain: o
Molecule details ›
Chain: o
Length: 451 amino acids
Theoretical weight: 50.3 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: Integrator complex subunit 15
Length: 451 amino acids
Theoretical weight: 50.3 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q96N11 (Residues: 1-449; Coverage: 100%)
Sequence domains: Integrator complex subunit 15
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Chain: p
Molecule details ›
Chain: p
Length: 591 amino acids
Theoretical weight: 65.58 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: HEAT repeat
Length: 591 amino acids
Theoretical weight: 65.58 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
P30153 (Residues: 1-589; Coverage: 100%)
Sequence domains: HEAT repeat
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Chain: q
Molecule details ›
Chain: q
Length: 311 amino acids
Theoretical weight: 35.84 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: Calcineurin-like phosphoesterase
Length: 311 amino acids
Theoretical weight: 35.84 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
P67775 (Residues: 1-309; Coverage: 100%)
Sequence domains: Calcineurin-like phosphoesterase
DSS1
Chain: r
Integrator complex subunit 13
Chain: m
Molecule details ›
Chain: m
Length: 706 amino acids
Theoretical weight: 80.35 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: Cell cycle and development regulator Mat89Bb
Length: 706 amino acids
Theoretical weight: 80.35 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q9NVM9 (Residues: 1-706; Coverage: 100%)
Sequence domains: Cell cycle and development regulator Mat89Bb