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ATAD2 bromodomain in complex with "oncohistone" mutation H4S1CK5ac (res 1-15) ligand

X-ray diffraction
2.01Å resolution
PDB entry 8sdo coloured by chain, front view.
PDB entry 8sdo coloured by chain, side view.
PDB entry 8sdo coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Histone H4 and ATPase family AAA domain-containing protein 2
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Multimeric state: hetero dimer
Accessible surface area: 8644.33 Å2
Buried surface area: 774.59 Å2
Dissociation area: 387.29 Å2
Dissociation energy (ΔGdiss): 1.71 kcal/mol
Dissociation entropy (TΔSdiss): 6.07 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158681

Macromolecules

ATPase family AAA domain-containing protein 2
Chain: A
Length: 152 amino acids
Theoretical weight: 17.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q6PL18 (Residues: 966-1112; Coverage: 11%)
Gene names: ATAD2, L16, PRO2000
Pfam: Bromodomain
ATPase family AAA domain-containing protein 2 in PDB entry 8sdo, assembly 1, front view.
ATPase family AAA domain-containing protein 2 in PDB entry 8sdo, assembly 1, side view.
ATPase family AAA domain-containing protein 2 in PDB entry 8sdo, assembly 1, top view.
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Histone H4
Chain: B
Length: 15 amino acids
Theoretical weight: 1.35 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P62805 (Residues: 3-16; Coverage: 14%)
Gene names: H4-16, H4/A, H4/B, H4/C, H4/D, H4/E, H4/G, H4/H, H4/I, H4/J, H4/K, H4/M, H4/N, H4/O, H4C1, H4C11, H4C12, H4C13, H4C14, H4C15, H4C16, H4C2, H4C3, H4C4, H4C5, H4C6, H4C8, H4C9, H4F2, H4FA, H4FB, H4FC, H4FD, H4FE, H4FG, H4FH, H4FI, H4FJ, H4FK, H4FM, H4FN, H4FO, HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4, HIST2H4A, HIST2H4B, HIST4H4
Histone H4 in PDB entry 8sdo, assembly 1, front view.
Histone H4 in PDB entry 8sdo, assembly 1, side view.
Histone H4 in PDB entry 8sdo, assembly 1, top view.
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