› 8sgs

Electron Microscopy
3.15Å resolution

human liver mitochondrial Short-chain specific acyl-CoA dehydrogenase

Released:
DOI: 10.2210/pdb8sgs/pdb
PDB entry 8sgs coloured by chain, front view.
PDB entry 8sgs coloured by chain, side view.
PDB entry 8sgs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
High-Resolution Structural Proteomics of Mitochondria Using the 'Build and Retrieve' Methodology.
Zhang Z, Tringides ML, Morgan CE, Miyagi M, Mears JA, Hoppel CL, Yu EW
OpenAccess logo Mol Cell Proteomics 22 100666 (2023)
PMID: 37839702
Related structures: EMD-40466

Function and Biology Details

Reaction catalysed: 
A short-chain acyl-CoA + electron-transfer flavoprotein = a short-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147660 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Short-chain specific acyl-CoA dehydrogenase, mitochondrial Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 412 amino acids
Theoretical weight: 44.35 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P16219 (Residues: 1-412; Coverage: 100%)
Gene name: ACADS
Sequence domains:

Ligands and Environments


Cofactor: Ligand FAD 4 x FAD
1 bound ligand:
Ligand COA 4 x COA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.15Å
Relevant EMDB volumes: EMD-40466

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