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Structure of human POT1 DNA binding domain bound to a 5'-phosphorylated junction of a telomeric DNA hairpin with a 3'-overhang

X-ray diffraction
2.16Å resolution
PDB entry 8sh0 coloured by chain, front view.
PDB entry 8sh0 coloured by chain, side view.
PDB entry 8sh0 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 1 distinct polypeptide molecule
1 distinct DNA molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Protection of telomeres protein 1 and DNA
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Multimeric state: hetero dimer
Accessible surface area: 17433.18 Å2
Buried surface area: 3306.22 Å2
Dissociation area: 1,431.24 Å2
Dissociation energy (ΔGdiss): 15.5 kcal/mol
Dissociation entropy (TΔSdiss): 11.61 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-270729

Macromolecules

Protection of telomeres protein 1
Chain: A
Length: 300 amino acids
Theoretical weight: 33.81 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9NUX5 (Residues: 1-299; Coverage: 47%)
Gene name: POT1
Pfam:
Protection of telomeres protein 1 in PDB entry 8sh0, assembly 1, front view.
Protection of telomeres protein 1 in PDB entry 8sh0, assembly 1, side view.
Protection of telomeres protein 1 in PDB entry 8sh0, assembly 1, top view.
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DNA chain B
Name: DNA (5'-D(P*CP*CP*AP*GP*CP*AP*GP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*G)-3')
Representative chains: B
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 20 nucleotides
Theoretical weight: 6.26 KDa
DNA (5'-D(P*CP*CP*AP*GP*CP*AP*GP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*G)-3') in PDB entry 8sh0, assembly 1, front view.
DNA (5'-D(P*CP*CP*AP*GP*CP*AP*GP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*G)-3') in PDB entry 8sh0, assembly 1, side view.
DNA (5'-D(P*CP*CP*AP*GP*CP*AP*GP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*G)-3') in PDB entry 8sh0, assembly 1, top view.
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