› 8shp

Electron Microscopy
3Å resolution

CCT G beta 5 complex closed state 13

Released:
DOI: 10.2210/pdb8shp/pdb
PDB entry 8shp coloured by chain, front view.
PDB entry 8shp coloured by chain, side view.
PDB entry 8shp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Visualizing the chaperone-mediated folding trajectory of the G protein β5 β-propeller.
Wang S, Sass MI, Kwon Y, Ludlam WG, Smith TM, Carter EJ, Gladden NE, Riggi M, Iwasa JH, Willardson BM, Shen PS
Mol Cell (2023)
PMID: 37852256
Related structures: EMD-40491

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero octadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-232712 (preferred)
Entry contents:
10 distinct polypeptide molecules
Macromolecules (10 distinct):
Guanine nucleotide-binding protein subunit beta-5 Chain: N
Molecule details ›
Chain: N
Length: 395 amino acids
Theoretical weight: 43.62 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O14775 (Residues: 1-395; Coverage: 100%)
Gene name: GNB5
Sequence domains: WD domain, G-beta repeat
T-complex protein 1 subunit alpha Chains: A, a
Molecule details ›
Chains: A, a
Length: 536 amino acids
Theoretical weight: 58.24 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P17987 (Residues: 2-537; Coverage: 96%)
Gene names: CCT1, CCTA, TCP1
Sequence domains: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit beta Chains: B, b
Molecule details ›
Chains: B, b
Length: 526 amino acids
Theoretical weight: 56.49 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P78371 (Residues: 2-527; Coverage: 98%)
Gene names: 99D8.1, CCT2, CCTB
Sequence domains: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit delta Chains: D, d
Molecule details ›
Chains: D, d
Length: 520 amino acids
Theoretical weight: 56.24 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P50991 (Residues: 19-538; Coverage: 97%)
Gene names: CCT4, CCTD, SRB
Sequence domains: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit epsilon Chains: E, e
Molecule details ›
Chains: E, e
Length: 540 amino acids
Theoretical weight: 59.62 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P48643 (Residues: 2-541; Coverage: 100%)
Gene names: CCT5, CCTE, KIAA0098
Sequence domains: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit gamma Chains: G, g
Molecule details ›
Chains: G, g
Length: 528 amino acids
Theoretical weight: 58.84 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P49368 (Residues: 3-530; Coverage: 97%)
Gene names: CCT3, CCTG, TRIC5
Sequence domains: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit eta Chains: H, h
Molecule details ›
Chains: H, h
Length: 528 amino acids
Theoretical weight: 57.94 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q99832 (Residues: 1-528; Coverage: 97%)
Gene names: CCT7, CCTH, NIP7-1
Sequence domains: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit theta Chains: Q, q
Molecule details ›
Chains: Q, q
Length: 538 amino acids
Theoretical weight: 58.43 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P50990 (Residues: 2-539; Coverage: 98%)
Gene names: C21orf112, CCT8, CCTQ, KIAA0002
Sequence domains: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit zeta Chains: Z, z
Molecule details ›
Chains: Z, z
Length: 527 amino acids
Theoretical weight: 57.72 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P40227 (Residues: 1-527; Coverage: 99%)
Gene names: CCT6, CCT6A, CCTZ
Sequence domains: TCP-1/cpn60 chaperonin family
Phosducin-like protein Chain: P
Molecule details ›
Chain: P
Length: 301 amino acids
Theoretical weight: 34.32 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q13371 (Residues: 1-301; Coverage: 100%)
Gene names: PDCL, PHLOP1, PhLP1
Sequence domains: Phosducin

Ligands and Environments

3 bound ligands:
Ligand ADP 16 x ADP
Ligand MG 16 x MG
Ligand AF3 16 x AF3
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3Å
Relevant EMDB volumes: EMD-40491

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