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CCT G beta 5 complex closed state 13

Electron Microscopy
3Å resolution
PDB entry 8shp coloured by chain, front view.
PDB entry 8shp coloured by chain, side view.
PDB entry 8shp coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero octadecamer (preferred)
Entry contents: 10 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Chaperonin-containing T-complex
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Multimeric state: hetero octadecamer
Accessible surface area: 297283.32 Å2
Buried surface area: 151362.0 Å2
Dissociation area: 1,895.95 Å2
Dissociation energy (ΔGdiss): 2.32 kcal/mol
Dissociation entropy (TΔSdiss): 13.88 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-232712

Macromolecules

Guanine nucleotide-binding protein subunit beta-5
Chain: N
Length: 395 amino acids
Theoretical weight: 43.62 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O14775 (Residues: 1-395; Coverage: 100%)
Gene name: GNB5
Pfam: WD domain, G-beta repeat
Guanine nucleotide-binding protein subunit beta-5 in PDB entry 8shp, assembly 1, front view.
Guanine nucleotide-binding protein subunit beta-5 in PDB entry 8shp, assembly 1, side view.
Guanine nucleotide-binding protein subunit beta-5 in PDB entry 8shp, assembly 1, top view.
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T-complex protein 1 subunit alpha
Chains: A, a
Length: 536 amino acids
Theoretical weight: 58.24 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P17987 (Residues: 2-537; Coverage: 96%)
Gene names: CCT1, CCTA, TCP1
Pfam: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit alpha in PDB entry 8shp, assembly 1, front view.
T-complex protein 1 subunit alpha in PDB entry 8shp, assembly 1, side view.
T-complex protein 1 subunit alpha in PDB entry 8shp, assembly 1, top view.
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T-complex protein 1 subunit beta
Chains: B, b
Length: 526 amino acids
Theoretical weight: 56.49 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P78371 (Residues: 2-527; Coverage: 98%)
Gene names: 99D8.1, CCT2, CCTB
Pfam: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit beta in PDB entry 8shp, assembly 1, front view.
T-complex protein 1 subunit beta in PDB entry 8shp, assembly 1, side view.
T-complex protein 1 subunit beta in PDB entry 8shp, assembly 1, top view.
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T-complex protein 1 subunit delta
Chains: D, d
Length: 520 amino acids
Theoretical weight: 56.24 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P50991 (Residues: 19-538; Coverage: 97%)
Gene names: CCT4, CCTD, SRB
Pfam: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit delta in PDB entry 8shp, assembly 1, front view.
T-complex protein 1 subunit delta in PDB entry 8shp, assembly 1, side view.
T-complex protein 1 subunit delta in PDB entry 8shp, assembly 1, top view.
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T-complex protein 1 subunit epsilon
Chains: E, e
Length: 540 amino acids
Theoretical weight: 59.62 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P48643 (Residues: 2-541; Coverage: 100%)
Gene names: CCT5, CCTE, KIAA0098
Pfam: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit epsilon in PDB entry 8shp, assembly 1, front view.
T-complex protein 1 subunit epsilon in PDB entry 8shp, assembly 1, side view.
T-complex protein 1 subunit epsilon in PDB entry 8shp, assembly 1, top view.
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T-complex protein 1 subunit gamma
Chains: G, g
Length: 528 amino acids
Theoretical weight: 58.84 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P49368 (Residues: 3-530; Coverage: 97%)
Gene names: CCT3, CCTG, TRIC5
Pfam: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit gamma in PDB entry 8shp, assembly 1, front view.
T-complex protein 1 subunit gamma in PDB entry 8shp, assembly 1, side view.
T-complex protein 1 subunit gamma in PDB entry 8shp, assembly 1, top view.
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T-complex protein 1 subunit eta
Chains: H, h
Length: 528 amino acids
Theoretical weight: 57.94 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q99832 (Residues: 1-528; Coverage: 97%)
Gene names: CCT7, CCTH, NIP7-1
Pfam: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit eta in PDB entry 8shp, assembly 1, front view.
T-complex protein 1 subunit eta in PDB entry 8shp, assembly 1, side view.
T-complex protein 1 subunit eta in PDB entry 8shp, assembly 1, top view.
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T-complex protein 1 subunit theta
Chains: Q, q
Length: 538 amino acids
Theoretical weight: 58.43 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P50990 (Residues: 2-539; Coverage: 98%)
Gene names: C21orf112, CCT8, CCTQ, KIAA0002
Pfam: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit theta in PDB entry 8shp, assembly 1, front view.
T-complex protein 1 subunit theta in PDB entry 8shp, assembly 1, side view.
T-complex protein 1 subunit theta in PDB entry 8shp, assembly 1, top view.
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T-complex protein 1 subunit zeta
Chains: Z, z
Length: 527 amino acids
Theoretical weight: 57.72 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P40227 (Residues: 1-527; Coverage: 99%)
Gene names: CCT6, CCT6A, CCTZ
Pfam: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit zeta in PDB entry 8shp, assembly 1, front view.
T-complex protein 1 subunit zeta in PDB entry 8shp, assembly 1, side view.
T-complex protein 1 subunit zeta in PDB entry 8shp, assembly 1, top view.
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Phosducin-like protein
Chain: P
Length: 301 amino acids
Theoretical weight: 34.32 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q13371 (Residues: 1-301; Coverage: 100%)
Gene names: PDCL, PHLOP1, PhLP1
Pfam: Phosducin
Phosducin-like protein in PDB entry 8shp, assembly 1, front view.
Phosducin-like protein in PDB entry 8shp, assembly 1, side view.
Phosducin-like protein in PDB entry 8shp, assembly 1, top view.
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