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human liver mitochondrial Aldehyde dehydrogenase ALDH2

Electron Microscopy
2.66Å resolution
PDB entry 8shs coloured by chain, front view.
PDB entry 8shs coloured by chain, side view.
PDB entry 8shs coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Aldehyde dehydrogenase, mitochondrial
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Multimeric state: homo tetramer
Accessible surface area: 61169.9 Å2
Buried surface area: 20196.51 Å2
Dissociation area: 4,922.19 Å2
Dissociation energy (ΔGdiss): 37.99 kcal/mol
Dissociation entropy (TΔSdiss): 16.73 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-138420

Macromolecules

Aldehyde dehydrogenase, mitochondrial
Chains: A, B, C, D
Length: 517 amino acids
Theoretical weight: 56.44 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P05091 (Residues: 1-517; Coverage: 100%)
Gene names: ALDH2, ALDM
Pfam: Aldehyde dehydrogenase family
Aldehyde dehydrogenase, mitochondrial in PDB entry 8shs, assembly 1, front view.
Aldehyde dehydrogenase, mitochondrial in PDB entry 8shs, assembly 1, side view.
Aldehyde dehydrogenase, mitochondrial in PDB entry 8shs, assembly 1, top view.
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