› 8shs

Electron Microscopy
2.66Å resolution

human liver mitochondrial Aldehyde dehydrogenase ALDH2

Released:
DOI: 10.2210/pdb8shs/pdb
PDB entry 8shs coloured by chain, front view.
PDB entry 8shs coloured by chain, side view.
PDB entry 8shs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
High-Resolution Structural Proteomics of Mitochondria Using the 'Build and Retrieve' Methodology.
Zhang Z, Tringides ML, Morgan CE, Miyagi M, Mears JA, Hoppel CL, Yu EW
OpenAccess logo Mol Cell Proteomics 22 100666 (2023)
PMID: 37839702
Related structures: EMD-40493

Function and Biology Details

Reaction catalysed: 
An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138420 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aldehyde dehydrogenase, mitochondrial Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 517 amino acids
Theoretical weight: 56.44 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P05091 (Residues: 1-517; Coverage: 100%)
Gene names: ALDH2, ALDM
Sequence domains: Aldehyde dehydrogenase family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.66Å
Relevant EMDB volumes: EMD-40493

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