› 8soi

Electron Microscopy
4.2Å resolution

Structure of human ULK1 complex core (2:1:1 stoichiometry)

Released:
DOI: 10.2210/pdb8soi/pdb
PDB entry 8soi coloured by chain, front view.
PDB entry 8soi coloured by chain, side view.
PDB entry 8soi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex
Chen M, Ren X, Cook A, Hurley JH
bioRxiv (2023)
Related structures: EMD-40658

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-218506 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
RB1-inducible coiled-coil protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 600 amino acids
Theoretical weight: 68.81 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8TDY2 (Residues: 1-600; Coverage: 38%)
Gene names: KIAA0203, RB1CC1, RBICC
Serine/threonine-protein kinase ULK1 Chain: C
Molecule details ›
Chain: C
Length: 205 amino acids
Theoretical weight: 23.11 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O75385 (Residues: 840-1044; Coverage: 20%)
Gene names: KIAA0722, ULK1
Sequence domains:
Autophagy-related protein 13 Chain: D
Molecule details ›
Chain: D
Length: 61 amino acids
Theoretical weight: 6.81 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O75143 (Residues: 462-517; Coverage: 11%)
Gene names: ATG13, KIAA0652

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.2Å
Relevant EMDB volumes: EMD-40658
Expression system: Homo sapiens

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