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Structure of human ULK1 complex core (2:1:1 stoichiometry)

Electron Microscopy
4.2Å resolution
PDB entry 8soi coloured by chain, front view.
PDB entry 8soi coloured by chain, side view.
PDB entry 8soi coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 67295.95 Å2
Buried surface area: 13549.02 Å2
Dissociation area: 1,919.29 Å2
Dissociation energy (ΔGdiss): 10.1 kcal/mol
Dissociation entropy (TΔSdiss): 14.57 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-271834

Macromolecules

RB1-inducible coiled-coil protein 1
Chains: A, B
Length: 600 amino acids
Theoretical weight: 68.81 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8TDY2 (Residues: 1-600; Coverage: 38%)
Gene names: KIAA0203, RB1CC1, RBICC
RB1-inducible coiled-coil protein 1 in PDB entry 8soi, assembly 1, front view.
RB1-inducible coiled-coil protein 1 in PDB entry 8soi, assembly 1, side view.
RB1-inducible coiled-coil protein 1 in PDB entry 8soi, assembly 1, top view.
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Serine/threonine-protein kinase ULK1
Chain: C
Length: 205 amino acids
Theoretical weight: 23.11 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O75385 (Residues: 840-1044; Coverage: 20%)
Gene names: KIAA0722, ULK1
Pfam:
Serine/threonine-protein kinase ULK1 in PDB entry 8soi, assembly 1, front view.
Serine/threonine-protein kinase ULK1 in PDB entry 8soi, assembly 1, side view.
Serine/threonine-protein kinase ULK1 in PDB entry 8soi, assembly 1, top view.
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Autophagy-related protein 13
Chain: D
Length: 61 amino acids
Theoretical weight: 6.81 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O75143 (Residues: 462-517; Coverage: 11%)
Gene names: ATG13, KIAA0652
Autophagy-related protein 13 in PDB entry 8soi, assembly 1, front view.
Autophagy-related protein 13 in PDB entry 8soi, assembly 1, side view.
Autophagy-related protein 13 in PDB entry 8soi, assembly 1, top view.
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