› › Function and Biology

Cryo-EM structure of human CST bound to POT1(ESDL)/TPP1 in the presence of telomeric ssDNA

Source organisms:
Biochemical function: telomeric DNA binding
Biological process: telomere capping
Cellular component: chromosome, telomeric region

Quick links

EC 3.4.22.29: Picornain 2A

Reaction catalysed:
Selective cleavage of Tyr-|-Gly bond in picornavirus polyprotein.
Systematic name:
-
Alternative Name(s):
  • 2A protease
  • 2A proteinase
  • Picornaviral 2A proteinase
  • Picornavirus endopeptidase 2A
  • Poliovirus protease 2A
  • Poliovirus protease 2A-Pro
  • Poliovirus proteinase 2A
  • Protease 2A
  • Proteinase 2A-Pro
  • Rhinovirus protease 2A
  • Y-G proteinase 2A

EC 3.6.1.15: Nucleoside-triphosphate phosphatase

Reaction catalysed:
NTP + H(2)O = NDP + phosphate
Systematic name:
Unspecific diphosphate phosphohydrolase
Alternative Name(s):
  • NTPase
  • Nucleoside 5-triphosphatase
  • Nucleoside triphosphate hydrolase
  • Nucleoside triphosphate phosphohydrolase
  • Nucleoside-5-triphosphate phosphohydrolase
  • Nucleoside-triphosphatase

EC 3.4.22.28: Picornain 3C

Reaction catalysed:
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
Alternative Name(s):
  • 3C protease
  • 3C proteinase
  • Coxsackievirus 3C proteinase
  • Cysteine proteinase 3C
  • Foot-and-mouth protease 3C
  • Foot-and-mouth-disease virus proteinase 3C
  • Hepatitis A virus 3C proteinase
  • Picornavirus endopeptidase 3C
  • Poliovirus protease 3C
  • Poliovirus proteinase 3C
  • Protease 3C
  • Rhinovirus protease 3C
  • Rhinovirus proteinase 3C
  • Tomato ringspot nepovirus 3C-related protease

EC 2.7.7.48: RNA-directed RNA polymerase

Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
Nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)
Alternative Name(s):
  • 3D polymerase
  • PB1 proteins
  • PB2 proteins
  • Phage f2 replicase
  • Polymerase L
  • Q-beta replicase
  • RDRP
  • RNA nucleotidyltransferase (RNA-directed)
  • RNA replicase
  • RNA synthetase
  • RNA transcriptase
  • RNA-dependent RNA polymerase
  • RNA-dependent RNA replicase
  • RNA-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid replicase
  • Ribonucleic acid-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid-dependent ribonucleic acid polymerase
  • Ribonucleic replicase
  • Ribonucleic synthetase
  • Transcriptase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF10341
Domain description: Shelterin complex subunit, TPP1/ACD
Occurring in:
  1. Adrenocortical dysplasia protein homolog
The deposited structure of PDB entry 8sok contains 1 copy of Pfam domain PF10341 (Shelterin complex subunit, TPP1/ACD) in Adrenocortical dysplasia protein homolog. Showing 1 copy in chain E (this domain is out of the observed residue ranges!).

PF01353
Domain description: Green fluorescent protein
Occurring in:
  1. Adrenocortical dysplasia protein homolog
The deposited structure of PDB entry 8sok contains 1 copy of Pfam domain PF01353 (Green fluorescent protein) in Adrenocortical dysplasia protein homolog. Showing 1 copy in chain E (this domain is out of the observed residue ranges!).

PF21375
Domain description: Protection of telomeres protein 1 (POT1), C-terminal insertion domain
Occurring in:
  1. Protection of telomeres protein 1
The deposited structure of PDB entry 8sok contains 1 copy of Pfam domain PF21375 (Protection of telomeres protein 1 (POT1), C-terminal insertion domain) in Protection of telomeres protein 1. Showing 1 copy in chain D.

PF16686
Domain description: ssDNA-binding domain of telomere protection protein
Occurring in:
  1. Protection of telomeres protein 1
The deposited structure of PDB entry 8sok contains 1 copy of Pfam domain PF16686 (ssDNA-binding domain of telomere protection protein) in Protection of telomeres protein 1. Showing 1 copy in chain D.

PF02765
Domain description: Telomeric single stranded DNA binding POT1/CDC13
Occurring in:
  1. Protection of telomeres protein 1
The deposited structure of PDB entry 8sok contains 1 copy of Pfam domain PF02765 (Telomeric single stranded DNA binding POT1/CDC13) in Protection of telomeres protein 1. Showing 1 copy in chain D.

PF15490
Domain description: Telomere-capping, CST complex subunit
Occurring in:
  1. CST complex subunit TEN1
The deposited structure of PDB entry 8sok contains 1 copy of Pfam domain PF15490 (Telomere-capping, CST complex subunit) in CST complex subunit TEN1. Showing 1 copy in chain C.

PF09170
Domain description: CST, complex subunit STN1, C terminal
Occurring in:
  1. CST complex subunit STN1
The deposited structure of PDB entry 8sok contains 1 copy of Pfam domain PF09170 (CST, complex subunit STN1, C terminal) in CST complex subunit STN1. Showing 1 copy in chain B.

PF01336
Domain description: OB-fold nucleic acid binding domain
Occurring in:
  1. CST complex subunit STN1
The deposited structure of PDB entry 8sok contains 1 copy of Pfam domain PF01336 (OB-fold nucleic acid binding domain) in CST complex subunit STN1. Showing 1 copy in chain B.

PF15489
Domain description: CST, telomere maintenance, complex subunit CTC1
Occurring in:
  1. CST complex subunit CTC1; Maltose/maltodextrin-binding periplasmic protein
The deposited structure of PDB entry 8sok contains 1 copy of Pfam domain PF15489 (CST, telomere maintenance, complex subunit CTC1) in CST complex subunit CTC1. Showing 1 copy in chain A.

PF01547
Domain description: Bacterial extracellular solute-binding protein
Occurring in:
  1. CST complex subunit CTC1; Maltose/maltodextrin-binding periplasmic protein
The deposited structure of PDB entry 8sok contains 1 copy of Pfam domain PF01547 (Bacterial extracellular solute-binding protein) in CST complex subunit CTC1. Showing 1 copy in chain A (this domain is out of the observed residue ranges!).

Quick links