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Crystal structure of pregnane X receptor ligand binding domain in complex with SJPYT-331

X-ray diffraction
2.39Å resolution
PDB entry 8svt coloured by chain, front view.
PDB entry 8svt coloured by chain, side view.
PDB entry 8svt coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Nuclear receptor coactivator 1, Nuclear receptor subfamily 1 group I member 2
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Multimeric state: homo dimer
Accessible surface area: 26570.38 Å2
Buried surface area: 1799.27 Å2
Dissociation area: 792.55 Å2
Dissociation energy (ΔGdiss): 0.04 kcal/mol
Dissociation entropy (TΔSdiss): 13.2 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-130965

Macromolecules

Nuclear receptor coactivator 1; Nuclear receptor subfamily 1 group I member 2
Chains: A, B
Length: 351 amino acids
Theoretical weight: 39.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O75469 (Residues: 130-434; Coverage: 70%)
  • Canonical: Q15788 (Residues: 678-710; Coverage: 2%)
    • nullnull
Gene names: BHLHE74, NCOA1, NR1I2, PXR, SRC1
Pfam:
Nuclear receptor coactivator 1 in PDB entry 8svt, assembly 1, front view.
Nuclear receptor coactivator 1 in PDB entry 8svt, assembly 1, side view.
Nuclear receptor coactivator 1 in PDB entry 8svt, assembly 1, top view.
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